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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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TLR3

toll-like receptor 3

TLR3 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Gene Name: toll-like receptor 3
Family/Subfamily: Toll-like Receptor , not assigned-Toll-like Receptor
Synonyms: TLR3, CD283, Toll-like receptor 3, CD283 antigen, IIAE2
Target Sequences: NM_003265 NP_003256.1 O15455

Publications (4)

1
Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Journal of virology. 2008 82:7613-23. [PubMed:18508883] [PMC:PMC2493309] Related Antibodies: LS-C40786.
2
KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation. Sharma NR, Majerciak V, Kruhlak MJ, Zheng ZM. PLoS pathogens. 2017 13:e1006677. (WB; Human) [Full Text Article] [PubMed:29084250] Related Antibodies: LS-C19344.
3
A comparison of the impact of Shimen and C strains of classical swine fever virus on Toll-like receptor expression. Cao Z, Guo K, Zheng M, Ning P, Li H, Kang K, Lin Z, Zhang C, Liang W, Zhang Y. The Journal of general virology. 2015 96:1732-45. (WB; Human) [Full Text Article] [PubMed:25805409] Related Antibodies: LS-C545.
4
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA. Sadik CD, Bachmann M, Pfeilschifter J, Mhl H. Nucleic acids research. 2009 37:5041-56. [PubMed:19541850] [PMC:PMC2731906] Related Antibodies: LS-C40786.
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Viewing 1-25 of 155 items
TLR3 Antibody - Anti-TLR3 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TLR3
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
TLR3 Antibody - Anti-TLR3 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TLR3
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
TLR3 Antibody - Anti-TLR3 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal to Human TLR3
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
TLR3 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rat Monoclonal [clone ABM24E5] (IgG2b,k) to Mouse TLR3
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $425.00
TLR3 Antibody - IHC of human gut lumen (longitudinal section, transverse region) using antibody at 10 ug/ml.
Select
(1) Publication(s)
Mouse Monoclonal [clone 40C1285.6] (IgG1) to Human TLR3
Goat, Sheep, Human, Monkey
Flo, IHC, IHC-P, IP, WB
Unconjugated
100µg   100µl   1mg/ml   $335.00
Select
Mouse Monoclonal [clone TLR3.7] (IgG1) to Human TLR3
Human
Block, Flo, ICC, IP
Unconjugated
50µg   1mg/ml   $325.00
TLR3 Antibody - Immunofluorescence of IgG, AID and TLR3 (Polyclonal Antibody to TLR3 (Phospho Tyr759)) expression in a healthy donor (A) and a hyper-IgM (HIGM) syndrome patient (B and C). A and B: Paraformaldehyde-fixed, frozen tonsillar mucosa tissue sections. C. Paraformaldehyde-fixed, mucosal B cells from the colon lamina propria of the HIGM patient. Arrowheads indicate cells co-expressing phospho TLR3, AID, and IgG.
Select
(1) Publication(s)
Rabbit Polyclonal to Human TLR3
Human
IF, IHC, IHC-Fr, WB
Unconjugated
20µg   0.2mg/ml   $335.00
Select
Mouse Monoclonal [clone TLR3.7] (IgG1) to Human TLR3
Mouse, Dog, Human
Flo, Func, IF, IHC, IHC-Fr, IHC-P, IP, WB
FITC Conjugated
100µg   $485.00
TLR3 Antibody - Western blot of TLR3 in 15 ug/lane mouse spleen tissue lysate.
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Rabbit Polyclonal (IgG) to Mouse TLR3
Mouse
Flo, IHC, IHC-Fr, WB
Unconjugated
100µg   200µl   0.5mg/ml   $335.00
TLR3 Antibody - Cell extract from transfected 293 cells stably expressing human TLR3 was resolved by electrophoresis, transferred to nitrocellulose, and probed with anti-TLR3 (clone TLR-104) antibody. Proteins were visualized using a goat anti-mouse secondary conjugated
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(2) Publication(s)
Mouse Monoclonal [clone TLR-104] (IgG2a) to Human TLR3
Human
Flo, WB
Unconjugated
100µg   0.5mg/ml   $325.00
TLR3 Antibody - Formalin-fixed and paraffin-embedded mouse brain tissue reacted with TLR3 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human TLR3
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal to Mouse TLR3
Mouse, Rat, Human
WB
Unconjugated
30µg   $245.00; 100µg   $385.00
TLR3 Antibody - Staining of permeabilized A549 cells with 1 ug of Purified Mouse IgG1, K isotype control (open histogram) or 1 ug of Purified anti-human TLR3 (TLR3.7) (colored histogram) followed by FITC Anti-Mouse IgG. Total cells were used for analysis.
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Mouse Monoclonal [clone TLR3.7] (IgG1,k) to Human TLR3
Human
Flo, IHC, IHC-Fr, WB
Unconjugated
25µg   $255.00; 100µg   $365.00
TLR3 Antibody - Staining of permeabilized A549 cells with 0.5 ug of PE Mouse IgG1, K isotype control (open histogram) or 0.5 ug of PE anti-human TLR3 (TLR3.7) (colored histogram). Total cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone TLR3.7] (IgG1,k) to Human TLR3
Human
Flo
PE Conjugated
25µg   $295.00; 100µg   0.2mg/ml   $395.00
TLR3 Antibody - Western Blot: TLR3 Antibody (27N3D4) [Azide Free] - Analysis of TLR3 using TLR3 monoclonal antibody. Human intestine (A), human spleen (B), and mouse RAW lysate probed with TLR3 antibody at 2 ug/ml. Goat anti-rat Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
Rat Monoclonal [clone 27N3D4] (IgG2b,k) to Mouse TLR3
Mouse, Human
Flo, WB
Unconjugated, Azide-free
100µg   1mg/ml   $365.00
TLR3 Antibody - Western Blot: TLR3 Antibody (27N3D4) - Analysis of TLR3 using TLR3 monoclonal antibody. Human intestine (A), human spleen (B), and mouse RAW lysate probed with TLR3 antibody at 2 ug/ml. I goat anti-rat Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Select
Rat Monoclonal [clone 27N3D4] (IgG2b,k) to Mouse TLR3
Mouse, Human
Flo, WB
Unconjugated
100µg   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human TLR3
Human
IHC-Fr, WB
Unconjugated
0.1mg   $375.00
Select
Mouse Monoclonal [clone 40C1285.6] (IgG1,k) to Human TLR3
Mouse, Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated, Azide-free
100µg   0.5mg/ml   $365.00
Select
Mouse Monoclonal (IgG1) to Human TLR3
Mouse, Canine, Human
Flo, Func, IF, IHC, IHC-Fr, IHC-P, IP
Unconjugated, Low Endotoxin
0.5mg   $1,275.00
Select
Mouse Monoclonal [clone 40C1285.6] (IgG1,k) to Human TLR3
Mouse, Dog, Human
ELISA
Biotin Conjugated
100µg   0.5mg/ml   $365.00
TLR3 Antibody - Immunohistochemistry-Paraffin: TLR3 Antibody - Mouse testis tissue probed with TLR3 antibody at 5 ug/ml.
Select
Rabbit Polyclonal to Mouse TLR3
Human
Flo, IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $335.00
Select
Mouse Monoclonal [clone TLR3.7] (IgG1) to Human TLR3
Mouse, Dog, Human
Flo, Func, IF, IHC, IHC-Fr, IHC-P, IP, WB
Biotin Conjugated
50µg   $355.00
Select
Mouse Monoclonal (IgG1) to Human TLR3
Human
Flo, ICC, IHC, IHC-P, IP, WB
FITC Conjugated
100µg   $740.00
Select
Mouse Monoclonal (IgG1) to Human TLR3
Human
Flo, Func, ICC, IP
Unconjugated
50µg   $530.00
TLR3 Antibody - Immunohistochemistry of paraffin-embedded human pancreatic cancer using TLR3 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human TLR3
Human
ELISA, IF, IHC
Unconjugated
50µg   $285.00; 100µg   $385.00

Viewing 1-25 of 155 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).