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TLE3 is a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Gene Name: | transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) |
Synonyms: | TLE3, ESG, ESG3, Enhancer of split groucho 3, HsT18976, KIAA1547, GRG3 |
Target Sequences: | NM_005078 NP_005069.2 Q04726 |
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