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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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TIRAP

toll-interleukin 1 receptor (TIR) domain containing adaptor protein

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Gene Name: toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Synonyms: TIRAP, Adapter protein wyatt, BACTS1, Adaptor protein Wyatt, MyD88 adapter-like protein, Wyatt
Target Sequences: NM_148910 AAP31973.1 P58753

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Viewing 1-8 of 8 items
TIRAP Protein
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E. coli
His
50µg   0.25mg/ml   $365.00; 250µg   0.25mg/ml   $935.00
TIRAP Protein - Purified recombinant protein TIRAP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc + DDK
23.7 kDa
20µg   $890.00
TIRAP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc + DDK
28.03 kDa
20µg   $195.00
TIRAP Protein - Recombinant Toll Interleukin 1 Receptor Domain Containing Adaptor Protein By SDS-PAGE
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E. coli
His + GST
31.3 kDa
10µg   $275.00; 50µg   $455.00; 100µg   $605.00; 200µg   $875.00; 1mg   $2,265.00; 500µg   $1,005.00
TIRAP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc + DDK
28.03 kDa
100µg   $365.00
TIRAP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST,N-terminus
1mg   $1,290.00; 500µg   $830.00; 200µg   $485.00; 100µg   $355.00; 50µg   $275.00; 10µg   $245.00
TIRAP Protein - 12.5% SDS-PAGE of human TIRAP stained with Coomassie Blue
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Wheat Germ Extract
GST
53.9 kDa
10µg   $425.00; 25µg   $590.00
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E. coli
His
26.3 kDa
2µg   $195.00; 10µg   $255.00; 1mg   $5,460.00

Viewing 1-8 of 8 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).