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TIPIN
TIMELESS interacting protein
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
| Gene Name: | TIMELESS interacting protein |
| Synonyms: | TIPIN, TIMELESS interacting protein, TIMELESS-interacting protein, CSM3 homolog |
| Target Sequences: | NM_017858 NP_060328.2 Q9BVW5 |
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