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TIP30 / HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Gene Name:	HIV-1 Tat interactive protein 2, 30kDa
Synonyms:	HTATIP2, CC3, SDR44U1, Tat-interacting protein (30kD), TIP30, Oxidoreductase HTATIP2
Target Sequences:	NM_006410 NP_006401.3 Q9BUP3

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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