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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TIMP2

TIMP metallopeptidase inhibitor 2

TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Gene Name: TIMP metallopeptidase inhibitor 2
Synonyms: TIMP2, Metalloproteinase inhibitor 2, TIMP-2, CSC-21K
Target Sequences: NM_003255 NP_003246.1 P16035

Filtered by: None
Target
TIMP2 (140)
Reactivity
Human (98)
Mouse (56)
Rat (62)
Bat (4)
Bovine (37)
Chicken (2)
Chimpanzee (6)
Cow (8)
Dog (20)
Gibbon (9)
Guinea pig (25)
Hamster (4)
Horse (22)
Monkey (21)
Pig (20)
Rabbit (22)
Sheep (12)
Zebrafish (11)
Application
IHC (38)
IHC-Fr (3)
IHC-P (26)
WB (132)
Flo (11)
ELISA (19)
ICC (3)
IF (22)
IP (8)
Peptide-ELISA (3)
Host
rabbit (96)
mouse (41)
goat (1)
sheep (2)
Isotype
IgG (22)
IgG1 (18)
IgG1,k (4)
IgG2a (3)
IgG2a,k (16)
Clonality
monoclonal mc (42)
polyclonal pc (96)
recombinant monoclonal rmc (2)
Clone
11C1081 (1)
1554CT494.262.47 (1)
1C3 (1)
3A4 (7)
5B11 (1)
5D7 (1)
F27P3A4 (1)
OTI1A6 (2)
OTI1B11 (2)
OTI1C4 (2)
OTI1D7 (2)
OTI2G7 (2)
OTI3G7 (2)
OTI3H8 (2)
SPM356 (2)
T2-101 (3)
TIMP2/2044 (2)
TIMP2/2488R (2)
Format
AP Conjugated (1)
APC (6)
APC Conjugated (7)
Azide-free (4)
Biotin Conjugated (14)
BSA-free (1)
Carrier-free (8)
Concentrated (1)
Cy3 Conjugated (6)
Cy7 Conjugated (6)
FITC Conjugated (12)
HRP Conjugated (12)
Magnetic beads Conjugated (1)
PE Conjugated (7)
Sepharose Conjugated (1)
Unconjugated (73)
Epitope
aa27-220 (33)
C-Terminus (13)
aa2-88 (8)
aa33-153 (8)
aa130-179 (4)
aa40-89 (4)
N-Terminus, aa56-66 (2)
aa205-220 (2)
40-120 aa, Internal (1)
Ala47 (1)
Internal (1)
N-Terminus (1)
aa 30-220 (1)
aa178-193 (1)
aa179-190 (1)
aa21-70 (1)
Publications
No (140)
Showing 1-25 of 140 results

IHC-plus™ TIMP2 Antibody (clone 5B11) LS-B5545
Mouse Monoclonal [clone 5B11] (IgG2a,k) to Human TIMP2
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg 0.46mg/ml  $495.00
Anti-TIMP2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of monoclonal antibody to TIMP2 on HeLa cell. [antibody concentration 10 ug/ml]

IHC-plus™ TIMP2 Antibody (clone F27P3A4) LS-B1660
Mouse Monoclonal [clone F27P3A4] (IgG2a) to Human TIMP2
Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-TIMP2 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of recombinant human TIMP-2 protein using anti-TIMP-2, clone F27P3A4.

TIMP2 Antibody (clone OTI1A6) LS-C173579
Mouse Monoclonal [clone OTI1A6] (IgG1) to Human TIMP2
Mouse, Dog, Rat, Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Human breast tissue using anti-TIMP2 mouse monoclonal antibody.
IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TIMP2 mouse monoclonal antibody.

IHC-plus™ TIMP2 Antibody (clone 3A4) LS-B4238
Mouse Monoclonal [clone 3A4] (IgG2a) to Human TIMP2
Chicken, Zebrafish, Pig, Rabbit, Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg 0.95mg/ml  $425.00
Anti-TIMP2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TIMP2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

TIMP2 Antibody (clone T2-101, Azide-free) LS-C88246
Mouse Monoclonal [clone T2-101] (IgG1) to Human TIMP2
Human
IP, WB
Unconjugated, Azide-free
0.1ml  $620.00; 0.2ml  $995.00

TIMP2 Antibody (clone 3A4, Azide-free) LS-C87786
Mouse Monoclonal [clone 3A4] (IgG2a,k) to Human TIMP2
Rabbit, Mouse, Guinea pig, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated, Azide-free
100µl 1mg/ml  $725.00; 200µl 1mg/ml  $1,170.00
Formalin-fixed, paraffin-embedded human pancreatic tumor stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells. This image was taken for the unmodified form of this product. Other forms have not been tested.

TIMP2 Antibody (clone T2-101) LS-C88244
Mouse Monoclonal [clone T2-101] (IgG1) to Human TIMP2
Human
IP, WB
Unconjugated
0.1ml  $280.00; 0.5ml  $555.00; 1ml  $920.00

TIMP2 Antibody (clone OTI1D7) LS-C173599
Mouse Monoclonal [clone OTI1D7] (IgG1) to Human TIMP2
Mouse, Dog, Rat, Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
100µl 0.87mg/ml  $345.00
IHC of paraffin-embedded Human breast tissue using anti-TIMP2 mouse monoclonal antibody.
IHC of paraffin-embedded Human pancreas tissue using anti-TIMP2 mouse monoclonal antibody.

IHC-plus™ TIMP2 Antibody (clone 1C3) LS-B5544
Mouse Monoclonal [clone 1C3] (IgG2a,k) to Human TIMP2
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg  $495.00
Anti-TIMP2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of monoclonal antibody to TIMP2 on HeLa cell. [antibody concentration 10 ug/ml]

IHC-plus™ TIMP2 Antibody (aa178-193) LS-B8328
Mouse Monoclonal (IgG1,k) to Human TIMP2
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Human, Monkey
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µg 2mg/ml  $485.00
Anti-TIMP-2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.

TIMP2 Antibody LS-C10592
Mouse Monoclonal (IgG1) to Human TIMP2
Human
ELISA, IP, WB
Unconjugated
500µl  $650.00

TIMP2 Antibody (N-Terminus, clone 3A4) LS-C95516
Mouse Monoclonal [clone 3A4] (IgG2a,k) to Human TIMP2
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Human
IHC, WB
Unconjugated
0.5ml  $425.00; 1ml  $665.00
Formalin-fixed, paraffin-embedded testis stained with TIMP-2 antibody.

TIMP2 Antibody (clone 1554CT494.262.47) LS-C392599
Mouse Monoclonal [clone 1554CT494.262.47] (IgG1,k) to Human TIMP2
Human
Flo, IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
200µl  $325.00
Antibody staining TIMP2 in human kidney sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH 6). Samples were incubated with primary antibody (1:25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized A549 (human lung adenocarcinoma epithelial cell line) cells labeling Pdx1 with antibody at 1:25 dilution, followed by Dylight 488-conjugated goat anti-mouse IgG secondary antibody at 1:200 dilution (green). Immunofluorescence image showing cytoplasm staining on A549 cell line. Cytoplasmic actin is detected with Dylight 554 Phalloidin (PD18466410) at 1:100 dilution (red). The nuclear counter stain is DAPI (blue).

TIMP2 Antibody (clone OTI2G7) LS-C173580
Mouse Monoclonal [clone OTI2G7] (IgG1) to Human TIMP2
Human
Flo, IHC, IHC-P, WB
Unconjugated
100µl 0.76mg/ml  $345.00
IHC of paraffin-embedded Human breast tissue using anti-TIMP2 mouse monoclonal antibody.
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TIMP2 mouse monoclonal antibody.

TIMP2 Antibody (clone OTI2G7, Carrier-free) LS-C786715
Mouse Monoclonal [clone OTI2G7] (IgG1) to Human TIMP2
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100µg  $395.00

TIMP2 Antibody (clone OTI1B11) LS-C337581
Mouse Monoclonal [clone OTI1B11] (IgG1) to Human TIMP2
Human
Flo, IHC, IHC-P, WB
Unconjugated
100µl 0.9mg/ml  $345.00
IHC of paraffin-embedded Human breast tissue using anti-TIMP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
IHC of paraffin-embedded Human Kidney tissue using anti-TIMP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

TIMP2 Antibody (aa27-220) LS-C296673
Rabbit Polyclonal to Mouse TIMP2
Mouse
WB
Unconjugated
20µl 0.5mg/ml  $195.00; 100µl 0.5mg/ml  $235.00; 200µl 0.5mg/ml  $265.00; 1ml 0.5mg/ml  $415.00
Western blot of recombinant TIMP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TIMP2 Antibody (Internal) LS-C352955
Rabbit Polyclonal to Human TIMP2
Mouse, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of TIMP2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of TIMP2 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

TIMP2 Antibody (clone 11C1081) LS-C184138
Rabbit Monoclonal [clone 11C1081] (IgG) to Human TIMP2
Mouse, Human, Monkey
WB
Unconjugated
100µl  $530.00

TIMP2 Antibody LS-C752620
Rabbit Polyclonal (IgG) to Human TIMP2
Human
ELISA, IF, IHC, WB
Unconjugated
100µg  $355.00

TIMP2 Antibody (40-120 aa, Internal) LS-C386448
Rabbit Polyclonal (IgG) to Human TIMP2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of TIMP-2 antibody

TIMP2 Antibody LS-C393254
Rabbit Polyclonal to Human TIMP2
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl  $325.00

IHC-plus™ TIMP2 Antibody (aa 30-220) LS-B14950
Rabbit Polyclonal (IgG) to Human TIMP2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $425.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot All lanes: Metalloproteinase inhibitor 2 antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 24 kDa Observed band size: 60 kDa

TIMP2 Antibody LS-C124662
Sheep Polyclonal (IgG) to Human TIMP2
Mouse, Rat, Human
IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
1ml  $515.00

TIMP2 Antibody LS-C331538
Rabbit Polyclonal (IgG) to Human TIMP2
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Immunofluorescence analysis of MCF-7 cells using TIMP2 antibody. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using TIMP2 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Showing 1-25 of 140 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).