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Registration enables users to use special features of this website, such as past
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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TIMP1
TIMP metallopeptidase inhibitor 1
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
| Gene Name: | TIMP metallopeptidase inhibitor 1 |
| Synonyms: | TIMP1, CLGI, EPA, HCI, Metalloproteinase inhibitor 1, TIMP-1 |
| Target Sequences: | NM_003254 NP_003245.1 P01033 |
Publications (4)
1
Chronic binge alcohol administration accentuates expression of pro-fibrotic and inflammatory genes in the skeletal muscle of simian immunodeficiency virus-infected macaques. Dodd T, Simon L, LeCapitaine NJ, Zabaleta J, Mussell J, Berner P, Ford S, Dufour J, Bagby GJ, Nelson S, Molina PE. Alcoholism, clinical and experimental research. 2014 38:2697-706. (IHC; Human)
[Full Text Article]
[PubMed:25421506]
[PMC:PMC4244658]
2
Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms. Bumdelger B, Kokubo H, Kamata R, Fujii M, Yoshimura K, Aoki H, Orita Y, Ishida T, Ohtaki M, Nagao M, Ishida M, Yoshizumi M. PloS one. 2016 11:e0147088. (IHC; Mouse)
[Full Text Article]
[PubMed:26783750]
[PMC:PMC4718675]
3
Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation. Tabata M Dos Santos, Renato F Righetti, Bianca G Rezende, Elaine C Campos, Leandro do N Camargo, Beatriz M Saraiva-Romanholo, Silvia Fukuzaki, Carla M Prado, Edna A Leick, Milton A Martins, Iolanda F L C Tibério. Therapeutic advances in respiratory disease. 2020 December;14:1753466620962665. [Full Text Article]
[PubMed:33357114]
[PMC:PMC7768836]
Related Antibodies: LS-C299465.
☰ Filters
Products
Proteins
(32)
Type
Over-Expression Lysate
(2)
Recombinant
(29)
Target
TIMP1
(32)
Publications
No
(32)
Tag
6His, C-terminus
(2)
6His, N-terminus
(1)
GST
(1)
GST, N-terminus + His, C-terminus
(1)
His
(12)
His, N-terminus
(1)
His-GST
(1)
His-SUMO
(1)
His-T7
(1)
Myc-DDK (Flag)
(2)
Species
Dog
(1)
Horse
(1)
Human
(15)
Mouse
(8)
Rabbit
(1)
Rat
(4)
Sheep
(1)
Source
293T Cells
(1)
E. coli
(17)
HEK 293 Cells
(3)
Human Cells
(6)
Insect Cells
(1)
Mammalian Cells
(2)
Wheat Germ Extract
(1)
Purification
Purified
(11)
Low Endotoxin Level
Low endotoxin level
(16)
Biologically Active
Biologically active
(2)
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.75kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
20 µg/$348; 100 µg/$570; 1 mg/$2,333
293T Cells
Myc-DDK (Flag)
23.17 kDa
20 µg/$150
E. coli
His-GST
47.3 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
E. coli
His-T7
23.2 kDa
10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142
E. coli
His
25.6 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
E. coli
His-SUMO
36.23 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Wheat Germ Extract
GST
44.33 kDa
10 µg/$479; 25 µg/$670
E. coli
6His, N-terminus
23 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
20.2kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
HEK 293 Cells
None
Less than 1 EU/µg (determined by LAL method).
Predicted molecular mass of approximately 22 kD. The protein migrates at about 25 kD in DTT-reducing conditions and about 22 kD in non-reducing condition by SDS-PAGE. The N-terminal amino acid is Cys.
10 µg/$355
HEK 293 Cells
None
Less than 1 EU/µg (determined by LAL method).
Predicted molecular mass of approximately 22 kD. The protein migrates at about 35 kD in DTT-reducing conditions and about 30 kD in non-reducing conditions by SDS-PAGE. The N-terminal amino acid is Cys.
10 µg/$355; 25 µg/$497
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.8 kDa
10 µg/$317; 50 µg/$524
Mammalian Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
20.2 kDa
10 µg/$317; 50 µg/$524
E. coli
His, N-terminus
19.88 kDa
20 µg/$270; 100 µg/$390
E. coli
GST, N-terminus + His, C-terminus
48.7 kDa
50 µg/$419
E. coli
193 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
21.34 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
E. coli
183 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
20.24 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
E. coli
180 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
19.91 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Insect Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$361; 250 µg/$985; 10 µg/$261
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
20.6 kDa
2 µg/$268; 10 µg/$349
E. coli
His
22.1 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
E. coli
His
23.1 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His
22.1 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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