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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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TIMP1
TIMP metallopeptidase inhibitor 1
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Chronic binge alcohol administration accentuates expression of pro-fibrotic and inflammatory genes in the skeletal muscle of simian immunodeficiency virus-infected macaques. Dodd T, Simon L, LeCapitaine NJ, Zabaleta J, Mussell J, Berner P, Ford S, Dufour J, Bagby GJ, Nelson S, Molina PE. Alcoholism, clinical and experimental research. 2014 38:2697-706. (IHC; Human)[Full Text Article]
[PubMed:25421506]
[PMC:PMC4244658]
2
Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms. Bumdelger B, Kokubo H, Kamata R, Fujii M, Yoshimura K, Aoki H, Orita Y, Ishida T, Ohtaki M, Nagao M, Ishida M, Yoshizumi M. PloS one. 2016 11:e0147088. (IHC; Mouse)[Full Text Article]
[PubMed:26783750]
[PMC:PMC4718675]
3
Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation. Tabata M Dos Santos, Renato F Righetti, Bianca G Rezende, Elaine C Campos, Leandro do N Camargo, Beatriz M Saraiva-Romanholo, Silvia Fukuzaki, Carla M Prado, Edna A Leick, Milton A Martins, Iolanda F L C Tibério. Therapeutic advances in respiratory disease. 2020 December;14:1753466620962665. [Full Text Article]
[PubMed:33357114]
[PMC:PMC7768836]
Related Antibodies: LS-C299465.
4
AKT-AMPKa-mTOR-dependent HIF-1a Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma. Eslam E Abd El-Fattah, Sameh Saber, Mahmoud E Youssef, Hanan Eissa, Eman El-Ahwany, Noha A Amin, Mohammed Alqarni, Gaber El-Saber Batiha, Ahmad J Obaidullah, Mohamed M Y Kaddah, Ahmed Gaafar Ahmed Gaafar, Ahmed A E Mourad, Gomaa Mostafa-Hedeab, Amir Mohamed Abdelhamid. Frontiers in pharmacology. 2022 February;12:720173. [Full Text Article]
[PubMed:35095479]
[PMC:PMC8790251]
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).