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Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
Gene Name: | translocase of inner mitochondrial membrane 22 homolog (yeast) |
Synonyms: | TIMM22, TEX4, Putative membrane protein, Testis-expressed sequence 4, TIM22 |
Target Sequences: | NM_013337 NP_037469.2 Q9Y584 |
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