TIMELESS

timeless circadian clock

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

TIMELESS (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human TIMELESS Protein (Recombinant GST, N-terminus) (aa1109-1207) - LS-G60938

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TIMELESS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87259

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

138.5 kDa

Price:

20 µg/$150

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Human TIMELESS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70500

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

138.5 kDa

Price:

20 µg/$1,107

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TIMELESS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117008

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

138.5 kDa

Price:

100 µg/$494

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