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Thromboxane A2 Receptor

The thromboxane A2 receptor (TBXA2R) is a member of the Prostanoid Receptor subfamily. TBXA2R performs an essential role in hemostasis by interacting with thromboxane A2 to induce platelet aggregation. Thromboxane A2 has been implicated in myocardial infarct, stroke, and asthma. Additionally, thromboxane-prostanoid receptors have been implicated in the pathogenesis of cardiovascular diseases. Changes in TBXA2R function have also been linked to a hereditary bleeding disorder. The thromboxane A2 receptor is encoded by a single gene that is alternatively spliced at the carboxyl terminus, resulting in two variants, TP (343 residues) and TP (407 residues) that share the first 328 amino acids.

Gene Name: Thromboxane A2 Receptor
Family/Subfamily: GPCR , Prostanoid
Synonyms: TBXA2R, BDPLT13, Prostanoid TP receptor, Txa2 receptor, Thromboxane A2 receptor, TXA2-R
Target Sequences: NM_001060 NP_001051.1 P21731

Publications (3)

1
Expression of thromboxane synthase and the thromboxane-prostanoid receptor in the mouse and rat retina. Wright WS, McElhatten RM, Harris NR. Experimental eye research. 2009 89:532-7. (IHC-Fr; Mouse) [Full Text Article] [PubMed:19523949] [PMC:PMC2755196]
2
New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling. Chakraborty R, Pydi SP, Gleim S, Bhullar RP, Hwa J, Dakshinamurti S, Chelikani P. Molecular and cellular biology. 2013 33:184-93. (Flo; Human) [Full Text Article] [PubMed:23109431] [PMC:PMC3554117] Related Antibodies: LS-B4842.
3
Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis. Benndorf RA, Schwedhelm E, Gnann A, Taheri R, Kom G, Didié M, Steenpass A, Ergün S, Böger RH. Circulation research. 2008 103:1037-46. (IHC-P; Human) [Full Text Article] [PubMed:18802021] Related Antibodies: LS-A1280.

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Thromboxane A2 Receptor (9)
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Thromboxane A2 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Thromboxane A2 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Thromboxane A2 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Thromboxane A2 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Thromboxane A2 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Thromboxane A2 Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Thromboxane A2 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Thromboxane A2 Receptor ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Thromboxane A2 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$834
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).