THRA / THR Alpha

Thyroid Hormone Receptor, Alpha

Thyroid hormone receptor alpha (TR alpha), a NR1 Thyroid Hormone-Like Receptor, mediates the diverse actions of thyroid hormone in development, differentiation, and metabolism. Four protein isoforms are encoded by the same TR alpha genomic locus: TR alpha1 (410 aa) (Nakai et al. 1988), TR alpha2 (490 aa) ( Nakai et al. 1988), TR deltaalpha1 (~154 aa), and TR deltaalpha2 (~237 aa); however, only TR alpha1 is able to bind the ligand ( Lazar et al. 1988). TR alpha1 and TR alpha2 are products of alternative splicing of the primary TR alpha mRNA, whereas TR deltaalpha1 and TR deltaalpha2 arise from transcription of an internal promoter in intron 7 of the TR alpha gene. A truncated form of TR alpha, called p43 for 43-kD, has been shown to regulate mitochondrial transcription Casas et al. 2003. Mice lacking all forms of TR alpha have been shown to be viable, but show reduced linear growth, delayed bone maturation, increased hypothermia, reduced thickness of the intestinal mucosa, lowered heart rates, and lowered serum T4. TR alpha has been linked to chronic fatigue Englebienne et al. 2003.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

THRA / THR Alpha (8)

Publications

No (8)

Tag

6His-B2M, N-terminus (1)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human THRA / THR Alpha Protein (Recombinant GST, N-terminus) (aa87-178) - LS-G60350

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human THRA / THR Alpha Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67119

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.6 kDa

Price:

20 µg/$1,107

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Human THRA / THR Alpha Protein (Recombinant His) (aa1-490) - LS-G24708

Source:

E. coli

Tag:

His

Molecular Weight:

58.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human THRA / THR Alpha Protein (Recombinant GST) (Full Length) - LS-G30700

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human THRA / THR Alpha Protein (Recombinant 6His-B2M, N-terminus) (Full Length) - LS-G137121

Source:

E. coli

Tag:

6His-B2M, N-terminus

Molecular Weight:

68.8 kDa

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human THRA / THR Alpha Protein (Recombinant DDK,C-terminus) - LS-G142329

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

55 kDa

Price:

20 µg/$677

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Human THRA / THR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79167

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.6 kDa

Price:

20 µg/$150

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THRA / THR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117459

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.6 kDa

Price:

100 µg/$494

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