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THOP1 / Thimet Oligopeptidase

thimet oligopeptidase 1

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

Gene Name: thimet oligopeptidase 1
Family/Subfamily: Protease , Metallopeptidase M3
Synonyms: THOP1, Endopeptidase 24.15, Endopeptidase 3.4.24.15, EP24.15, MEPD_HUMAN, Metalloendopeptidase 3.4.24.15, MP78, Thimet oligopeptidase, Thimet oligopeptidase 1, TOP
Target Sequences: NM_003249 NP_003240.1 P52888

Publications (2)

1
Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain. Conn KJ, Pietropaolo M, Ju ST, Abraham CR. Journal of neurochemistry. 1996 66:2011-8. [PubMed:8780030]
2
Mitosis-dependent protein expression in neuroblastoma cell line N1E-115. Azizi AA, Kang SU, Freilinger A, Gruber-Olipitz M, Chen WQ, Yang JW, Hengstschlger M, Slavc I, Lubec G. Journal of proteome research. 2008 7:3412-22. [PubMed:18582092]

☰ Filters
Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
THOP1 / Thimet Oligopeptidase (9)
No (9)
6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
His (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (7)
Mouse (1)
293T Cells (1)
Baculovirus (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (3)
THOP1 / Thimet Oligopeptidase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
THOP1 / Thimet Oligopeptidase Protein - Purified recombinant protein THOP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
78.7 kDa
20 µg/$1,107
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
80kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
THOP1 / Thimet Oligopeptidase Protein - Recombinant Thimet Oligopeptidase 1 By SDS-PAGE
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E. coli
His-T7
20.5 kDa
50 µg/$442; 10 µg/$281; 200 µg/$882; 100 µg/$705; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
THOP1 / Thimet Oligopeptidase Protein - 12.5% SDS-PAGE of human THOP1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
105.2 kDa
10 µg/$479; 25 µg/$670
THOP1 / Thimet Oligopeptidase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
78.7 kDa
100 µg/$494
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
80.0 kDa
10 µg/$344; 50 µg/$584
Select
293T Cells
Myc-DDK (Flag)
78.7 kDa
20 µg/$150
Select
Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
80.1 kDa
50 µg/$854
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).