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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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THOP1 / Thimet Oligopeptidase

thimet oligopeptidase 1

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

Gene Name: thimet oligopeptidase 1
Family/Subfamily: Protease , Metallopeptidase M3
Synonyms: THOP1, Endopeptidase 24.15, Endopeptidase 3.4.24.15, EP24.15, MEPD_HUMAN, Metalloendopeptidase 3.4.24.15, MP78, Thimet oligopeptidase, Thimet oligopeptidase 1, TOP
Target Sequences: NM_003249 NP_003240.1 P52888

Publications (2)

1
Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain. Conn KJ, Pietropaolo M, Ju ST, Abraham CR. Journal of neurochemistry. 1996 66:2011-8. [PubMed:8780030]
2
Mitosis-dependent protein expression in neuroblastoma cell line N1E-115. Azizi AA, Kang SU, Freilinger A, Gruber-Olipitz M, Chen WQ, Yang JW, Hengstschlger M, Slavc I, Lubec G. Journal of proteome research. 2008 7:3412-22. [PubMed:18582092]

Filtered By: None
Target
THOP1 / Thimet Oligopeptidase (29)
Reactivity
Human (27)
Mouse (13)
Rat (3)
Gibbon (3)
Orangutan (3)
Pig (8)
Primate (2)
Rabbit (2)
Application
IHC (15)
IHC-P (6)
WB (28)
ELISA (6)
ICC (8)
IP (3)
Host
rabbit (19)
mouse (9)
sheep (1)
Isotype
IgG (13)
IgG1 (1)
IgG2b (7)
IgM,k (1)
Clonality
monoclonal mc (9)
polyclonal pc (20)
Clone
2B4 (1)
2D3 (1)
4D6 (5)
Format
APC (1)
APC Conjugated (1)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (13)
Epitope
aa451-597 (10)
aa56-72 (6)
C-Terminus (4)
aa1-689 (1)
Publications
No (29)
Showing 1-25 of 29 results

THOP1 / Thimet Oligopeptidase Antibody (aa56-72, clone 4D6) IHC-plus™ LS-B220
Mouse Monoclonal [clone 4D6] (IgG2b) to Human THOP1 / Thimet Oligopeptidase
Rabbit, Mouse, Rat, Primate, Human
ICC IHC IHC-P WB
Unconjugated
100µl  $425.00
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

THOP1 / Thimet Oligopeptidase Antibody (aa56-72, clone 4D6, Biotin) LS-C142206
Mouse Monoclonal [clone 4D6] (IgG2b) to Human THOP1 / Thimet Oligopeptidase
Rabbit, Mouse, Rat, Primate, Human
ICC IHC IHC-P WB
Biotin Conjugated
100µl  $365.00
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of thimet oligopeptidase in HeLa whole cell lysate (30 ug). Lane 1: 0.5 ug/ml; lane 2: 2 ug/ml. 1 minute ECL exposure.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of thimet oligopeptidase in HeLa whole cell lysate (30 ug). Lane 1: 0.5 ug/ml; lane 2: 2 ug/ml. 1 minute ECL exposure.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

THOP1 / Thimet Oligopeptidase Antibody (aa56-72, clone 4D6, DY550) LS-C142210
Mouse Monoclonal [clone 4D6] (IgG2b) to Human THOP1 / Thimet Oligopeptidase
Human
ICC IHC IHC-P WB
DY550 Conjugated
100µl  $365.00
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of thimet oligopeptidase in HeLa whole cell lysate (30 ug). Lane 1: 0.5 ug/ml; lane 2: 2 ug/ml. 1 minute ECL exposure.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of thimet oligopeptidase in HeLa whole cell lysate (30 ug). Lane 1: 0.5 ug/ml; lane 2: 2 ug/ml. 1 minute ECL exposure.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

THOP1 / Thimet Oligopeptidase Antibody (aa56-72, clone 4D6, DY488) LS-C142208
Mouse Monoclonal [clone 4D6] (IgG2b) to Human THOP1 / Thimet Oligopeptidase
Human
ICC IHC IHC-P WB
DY488 Conjugated
100µl  $365.00
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of thimet oligopeptidase in HeLa whole cell lysate (30 ug). Lane 1: 0.5 ug/ml; lane 2: 2 ug/ml. 1 minute ECL exposure.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of thimet oligopeptidase in HeLa whole cell lysate (30 ug). Lane 1: 0.5 ug/ml; lane 2: 2 ug/ml. 1 minute ECL exposure.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

THOP1 / Thimet Oligopeptidase Antibody (aa56-72, clone 4D6, DY650) LS-C142207
Mouse Monoclonal [clone 4D6] (IgG2b) to Human THOP1 / Thimet Oligopeptidase
Human
ICC IHC IHC-P WB
DY650 Conjugated
100µl  $365.00
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of thimet oligopeptidase in HeLa whole cell lysate (30 ug). Lane 1: 0.5 ug/ml; lane 2: 2 ug/ml. 1 minute ECL exposure.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-THOP1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of thimet oligopeptidase in HeLa whole cell lysate (30 ug). Lane 1: 0.5 ug/ml; lane 2: 2 ug/ml. 1 minute ECL exposure.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

THOP1 / Thimet Oligopeptidase Antibody LS-C661025
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Human
ELISA IHC WB
Unconjugated
100µg  $435.00

THOP1 / Thimet Oligopeptidase Antibody (clone 2D3) LS-C115398
Mouse Monoclonal [clone 2D3] (IgG2b) to Human THOP1 / Thimet Oligopeptidase
Human
IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of paraffin-embedded Human liver tissue using anti-THOP1 mouse monoclonal antibody.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY THOP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-THOP1.
IHC of paraffin-embedded Human liver tissue using anti-THOP1 mouse monoclonal antibody.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY THOP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-THOP1.

THOP1 / Thimet Oligopeptidase Antibody LS-C489432
Rabbit Polyclonal to Mouse THOP1 / Thimet Oligopeptidase
Mouse
ELISA IP WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

THOP1 / Thimet Oligopeptidase Antibody LS-C76364
Mouse Monoclonal (IgG1) to Human THOP1 / Thimet Oligopeptidase
Human
ELISA IP WB
Unconjugated
100µg  $620.00

THOP1 / Thimet Oligopeptidase Antibody (aa56-72) LS-C92739
Mouse Monoclonal (IgG2b) to Human THOP1 / Thimet Oligopeptidase
Human
ICC WB
Unconjugated
100µl 1mg/ml  $515.00

THOP1 / Thimet Oligopeptidase Antibody (aa451-597) LS-C314998
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Mouse, Pig, Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
Western blot of recombinant THOP1 / Thimet Oligopeptidase.
Western blot of recombinant THOP1 / Thimet Oligopeptidase.

THOP1 / Thimet Oligopeptidase Antibody (aa451-597, HRP) LS-C713806
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Mouse, Pig, Human
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $680.00; 10ml  $2,730.00
Western blot of recombinant THOP1 / Thimet Oligopeptidase.
Western blot of recombinant THOP1 / Thimet Oligopeptidase.

THOP1 / Thimet Oligopeptidase Antibody (aa451-597, Biotin) LS-C424385
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Human
ICC WB
Biotin Conjugated
100µl 0.5mg/ml  $375.00

THOP1 / Thimet Oligopeptidase Antibody (aa451-597, Biotin) LS-C688899
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Mouse, Pig, Human
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $265.00; 200µl  $315.00; 1ml  $575.00; 10ml  $2,310.00
Western blot of recombinant THOP1 / Thimet Oligopeptidase.
Western blot of recombinant THOP1 / Thimet Oligopeptidase.

THOP1 / Thimet Oligopeptidase Antibody (aa451-597, FITC) LS-C424331
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Human
ICC WB
FITC Conjugated
100µl 0.5mg/ml  $395.00

THOP1 / Thimet Oligopeptidase Antibody (aa451-597, FITC) LS-C695929
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Mouse, Pig, Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
Western blot of recombinant THOP1 / Thimet Oligopeptidase.
Western blot of recombinant THOP1 / Thimet Oligopeptidase.

THOP1 / Thimet Oligopeptidase Antibody (aa451-597, Cy3) LS-C704790
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Mouse, Pig, Human
IHC WB
Cy3 Conjugated
20µl  $245.00; 100µl  $355.00; 200µl  $445.00; 1ml  $1,050.00; 10ml  $4,200.00
Western blot of recombinant THOP1 / Thimet Oligopeptidase.
Western blot of recombinant THOP1 / Thimet Oligopeptidase.

THOP1 / Thimet Oligopeptidase Antibody (aa451-597, APC) LS-C718986
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Mouse, Pig, Human
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $305.00; 200µl  $375.00; 1ml  $785.00; 10ml  $4,725.00
Western blot of recombinant THOP1 / Thimet Oligopeptidase.
Western blot of recombinant THOP1 / Thimet Oligopeptidase.

THOP1 / Thimet Oligopeptidase Antibody (aa451-597, PE) LS-C727876
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Mouse, Pig, Human
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
Western blot of recombinant THOP1 / Thimet Oligopeptidase.
Western blot of recombinant THOP1 / Thimet Oligopeptidase.

THOP1 / Thimet Oligopeptidase Antibody (aa451-597, APC, Cy7) LS-C736790
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Mouse, Pig, Human
IHC WB
APC, Cy7 Conjugated
20µl  $285.00; 100µl  $455.00; 200µl  $635.00; 1ml  $1,575.00; 10ml  $6,300.00
Western blot of recombinant THOP1 / Thimet Oligopeptidase.
Western blot of recombinant THOP1 / Thimet Oligopeptidase.

THOP1 / Thimet Oligopeptidase Antibody (clone 2B4) LS-C198341
Mouse Monoclonal [clone 2B4] (IgM,k) to Human THOP1 / Thimet Oligopeptidase
Human
ELISA WB
Unconjugated
200µl  $355.00

THOP1 / Thimet Oligopeptidase Antibody (aa1-689) LS-C39599
Sheep Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Human
ELISA IP WB
Unconjugated
100µg 100µl  $725.00

THOP1 / Thimet Oligopeptidase Antibody LS-C489431
Rabbit Polyclonal to Mouse THOP1 / Thimet Oligopeptidase
Mouse
ELISA
Unconjugated
100µl  $255.00; 200µl  $305.00; 400µl  $355.00

THOP1 / Thimet Oligopeptidase Antibody (C-Terminus) LS-C169932
Rabbit Polyclonal to Human THOP1 / Thimet Oligopeptidase
Human
WB
Unconjugated
50µg  $365.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

THOP1 / Thimet Oligopeptidase Antibody LS-C410290
Rabbit Polyclonal (IgG) to Human THOP1 / Thimet Oligopeptidase
Mouse, Rat, Human
WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of various cell lines.
Western blot analysis of extracts of various cell lines.
Showing 1-25 of 29 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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