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THOC7

THO Complex 7 Homolog (Drosophila)

Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Gene Name: THO Complex 7 Homolog (Drosophila)
Synonyms: THOC7, FSAP24, NIF3L1BP1, HTREX30, THO complex subunit 7 homolog, NIF3L1-binding protein 1
Target Sequences: NM_025075 NP_079351.2 Q6I9Y2

Publications (1)

1
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. Ramachandran S, Tran DD, Klebba-Faerber S, Kardinal C, Whetton AD, Tamura T. RNA (New York, N.Y.). 2011 17:1957-66. [PubMed:21937706] [PMC:PMC3198589]

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Antibodies (18)
Primary (18)
THOC7 (18)
Human (18)
Mouse (4)
Rat (4)
Bovine (6)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (3)
Orangutan (3)
Pig (3)
Rabbit (3)
IHC (3)
WB (14)
ELISA (7)
IP (1)
rabbit (18)
IgG (10)
polyclonal pc (18)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
Unconjugated (9)
C-Terminus (8)
aa1-50 (1)
aa154-204 (1)
No (18)
THOC7 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using THOC7 Polyclonal Antibody at dilution of 1:30.
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THOC7 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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THOC7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
THOC7 Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using THOC7 Polyclonal Antibody at dilution of 1:30.
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THOC7 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
THOC7 Antibody - Detection of human THOC7 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-THOC7 antibody used for WB at 0.1 µg/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
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THOC7 Rabbit anti-Human Polyclonal (aa154-204) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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THOC7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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THOC7 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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THOC7 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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THOC7 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
THOC7 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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THOC7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
THOC7 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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THOC7 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
THOC7 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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THOC7 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
THOC7 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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THOC7 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
THOC7 Antibody - Western blot of THOC7 Antibody with human 721_B Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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THOC7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
THOC7 Antibody - Western blot of THOC7 Antibody with human 721_B Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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THOC7 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Bovine, Human
WB
HRP Conjugated
100 µl/$469
THOC7 Antibody - Western blot of THOC7 Antibody with human 721_B Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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THOC7 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Bovine, Human
WB
Biotin Conjugated
100 µl/$469
THOC7 Antibody - Western blot of THOC7 Antibody with human 721_B Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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THOC7 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Bovine, Human
WB
FITC Conjugated
100 µl/$469
THOC7 Antibody - Western blot analysis of extracts of various cell lines, using THOC7 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 60s.
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THOC7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
THOC7 Antibody - Detection of human and mouse THOC7 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-THOC7 antibody used for WB at 0.1 µg/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
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THOC7 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
WB
Unconjugated
10 µl/$295; 100 µl/$514
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).