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TGFBI

transforming growth factor, beta-induced, 68kDa

TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.

Gene Name: transforming growth factor, beta-induced, 68kDa
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: TGFBI, BIGH3, Beta ig-h3, CDG2, CSD, CSD2, CSD3, CDGG1, EBMD, Kerato-epithelin, LCD1, RGD-CAP, CDB1, CSD1
Target Sequences: NM_000358 NP_000349.1 Q15582

Publications (2)

1
Target proteomic profiling of frozen pancreatic CD24+ adenocarcinoma tissues by immuno-laser capture microdissection and nano-LC-MS/MS. Zhu J, Nie S, Wu J, Lubman DM. Journal of proteome research. 2013 12:2791-804. (WB; Human) [Full Text Article] [PubMed:23679566] [PMC:PMC3726273] Related Antibodies: LS-B5942.
2
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Sidharth V Puram, Itay Tirosh, Anuraag S Parikh, Anoop P Patel, Keren Yizhak, Shawn Gillespie, Christopher Rodman, Christina L Luo, Edmund A Mroz, Kevin S Emerick, Daniel G Deschler, Mark A Varvares, Ravi Mylvaganam, Orit Rozenblatt-Rosen, James W Rocco, William C Faquin, Derrick T Lin, Aviv Regev, Bradley E Bernstein. Cell. 2017 Dec;171:1611-1624e24. [Full Text Article] [PubMed:29198524] [PMC:PMC5878932] Related Antibodies: LS-C325695.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).