TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.
|Gene Name:||transforming growth factor, beta-induced, 68kDa|
|Family/Subfamily:||TGF beta , not assigned-TGF beta|
|Synonyms:||TGFBI, BIGH3, Beta ig-h3, CDG2, CSD, CSD2, CSD3, CDGG1, EBMD, Kerato-epithelin, LCD1, RGD-CAP, CDB1, CSD1|
|Target Sequences:||NM_000358 NP_000349.1 Q15582|
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