Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.
|Gene Name:||transforming growth factor, beta-induced, 68kDa|
|Family/Subfamily:||TGF beta , not assigned-TGF beta|
|Synonyms:||TGFBI, BIGH3, Beta ig-h3, CDG2, CSD, CSD2, CSD3, CDGG1, EBMD, Kerato-epithelin, LCD1, RGD-CAP, CDB1, CSD1|
|Target Sequences:||NM_000358 NP_000349.1 Q15582|
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