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TGFB4 / LEFTY2

left-right determination factor 2

TGFB4 / LEFTY2 is a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Gene Name: left-right determination factor 2
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: LEFTY2, EBAF, LEFTYA, Protein lefty-2, LEFTA, TGFB4, Protein lefty-A, TGF-beta-4
Target Sequences: NM_003240 NP_003231.2 O00292

Publications (2)

1
Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S, Magalln J, Chandraratna RA, Chien K, Blumberg B, Evans RM, Belmonte JC. Proceedings of the National Academy of Sciences of the United States of America. 1999 96:11376-81. [PubMed:10500184] [PMC:PMC18041] Related Antibodies: LS-B2540.
2
Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor. Ulloa L, Tabibzadeh S. The Journal of biological chemistry. 2001 276:21397-404. [PubMed:11278746] Related Antibodies: LS-B2540.

☰ Filters
Products
Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
TGFB4 / LEFTY2 (10)
No (10)
6His, N-terminus (2)
GST (1)
His (3)
Myc-DDK (Flag) (4)
Human (6)
Mouse (1)
Rat (1)
293T Cells (2)
E. coli (3)
HEK 293 Cells (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
Select
Human Cells
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.1kD
10 µg/$233; 50 µg/$277; 500 µg/$725; 1 mg/$1,113
TGFB4 / LEFTY2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
40.92 kDa
20 µg/$150
TGFB4 / LEFTY2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
37.5 kDa
20 µg/$150
TGFB4 / LEFTY2 Protein - Recombinant Left/Right Determination Factor 2 By SDS-PAGE
Select
E. coli
His
13.9 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Select
E. coli
His
14.0 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
TGFB4 / LEFTY2 Protein - Recombinant Left/Right Determination Factor 2 By SDS-PAGE
Select
E. coli
His
13.9 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
TGFB4 / LEFTY2 Protein - 12.5% SDS-PAGE of human LEFTY2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
67.3 kDa
2 µg/$439
Select
Mammalian Cells
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.1 kDa
10 µg/$233; 50 µg/$277
TGFB4 / LEFTY2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
37.5 kDa
100 µg/$494
TGFB4 / LEFTY2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
40.92 kDa
100 µg/$494
Viewing 1-10 of 10 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).