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TGFB4 / LEFTY2
left-right determination factor 2
TGFB4 / LEFTY2 is a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.
| Gene Name: | left-right determination factor 2 |
| Family/Subfamily: | TGF beta , not assigned-TGF beta |
| Synonyms: | LEFTY2, EBAF, LEFTYA, Protein lefty-2, LEFTA, TGFB4, Protein lefty-A, TGF-beta-4 |
| Target Sequences: | NM_003240 NP_003231.2 O00292 |
Publications (2)
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