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TGFB4 / LEFTY2

left-right determination factor 2

TGFB4 / LEFTY2 is a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Gene Name: left-right determination factor 2
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: LEFTY2, EBAF, LEFTYA, Protein lefty-2, LEFTA, TGFB4, Protein lefty-A, TGF-beta-4
Target Sequences: NM_003240 NP_003231.2 O00292

Publications (2)

1
Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S, Magalln J, Chandraratna RA, Chien K, Blumberg B, Evans RM, Belmonte JC. Proceedings of the National Academy of Sciences of the United States of America. 1999 96:11376-81. [PubMed:10500184] [PMC:PMC18041] Related Antibodies: LS-B2540.
2
Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor. Ulloa L, Tabibzadeh S. The Journal of biological chemistry. 2001 276:21397-404. [PubMed:11278746] Related Antibodies: LS-B2540.

☰ Filters
Antibodies (50)
Proteins (10)
ELISA Kits (3)
Over-Expression Lysate (4)
Primary (50)
Recombinant (6)
Sandwich (3)
TGFB4 / LEFTY2 (63)
Human (36)
Mouse (13)
Rat (16)
Chimpanzee (6)
Dog (3)
Gibbon (3)
Pig (6)
IHC (8)
IHC-P (8)
WB (49)
ELISA (5)
IP (1)
Peptide-ELISA (3)
rabbit (47)
mouse (3)
Product Group
IHCPlus (2)
IgG (17)
IgG2a,k (3)
monoclonal mc (3)
polyclonal pc (47)
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7C5G1H6H10 (1)
96-Well Microplate (1)
96-Well Strip Plate (2)
APC (3)
APC Conjugated (4)
Biotin Conjugated (6)
Cy3 Conjugated (3)
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HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (18)
aa245-356 (16)
N-Terminus (8)
aa247-358 (8)
aa25-366 (1)
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Human (6)
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293T Cells (2)
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HEK 293 Cells (2)
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Wheat Germ Extract (1)
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Low endotoxin level (2)
TGFB4 / LEFTY2 Antibody - Anti-LEFTY2 antibody IHC of human uterus, myometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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TGFB4 / LEFTY2 Mouse anti-Human Monoclonal (7C5G1H6H10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
TGFB4 / LEFTY2 Antibody - Anti-LEFTY2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TGFB4 / LEFTY2 Antibody - Anti-LEFTY2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Rat, Pig, Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
TGFB4 / LEFTY2 Antibody - Anti-LEFTY2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Rat, Pig, Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TGFB4 / LEFTY2 Antibody - Anti-LEFTY2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Rat, Pig, Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
TGFB4 / LEFTY2 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
TGFB4 / LEFTY2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$1,041
TGFB4 / LEFTY2 Antibody - IHC of paraffin-embedded Colon ca using LEFTY2 antibody at 1:500 dilution.
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal (aa25-366) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
TGFB4 / LEFTY2 Antibody - 1:100 staining human Melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
100 µg/$331
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TGFB4 / LEFTY2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$973
TGFB4 / LEFTY2 Antibody - Anti-Lefty2 Antibody at 1:1000 dilution + HeLa whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 41 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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TGFB4 / LEFTY2 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$749
TGFB4 / LEFTY2 Antibody - All lanes : Anti-LEFTY2 Antibody at 1:8000 dilution Lane 1: HeLa whole cell lysates Lane 2: A431 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 41 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
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TGFB4 / LEFTY2 Mouse anti-Human Monoclonal (1D10) Antibody
Human
ELISA
Unconjugated
100 µg/$423
TGFB4 / LEFTY2 Antibody - Western blot of recombinant TGFB4 / LEFTY2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Mouse Polyclonal (aa247-358) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
TGFB4 / LEFTY2 Antibody - Western blot of recombinant TGFB4 / LEFTY2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Mouse Polyclonal (aa247-358) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
TGFB4 / LEFTY2 Antibody - Western blot of recombinant TGFB4 / LEFTY2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Mouse Polyclonal (aa247-358) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
TGFB4 / LEFTY2 Antibody - Western blot of recombinant TGFB4 / LEFTY2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Mouse Polyclonal (aa247-358) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
TGFB4 / LEFTY2 Antibody - Western blot of recombinant TGFB4 / LEFTY2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Mouse Polyclonal (aa247-358) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
TGFB4 / LEFTY2 Antibody - Western blot analysis of extracts of various cells.
Select
TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TGFB4 / LEFTY2 Antibody - TGFB4 / LEFTY2 antibody Western Blot of Thymus Tumor. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
TGFB4 / LEFTY2 Antibody
Select
TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal (aa245-356) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
TGFB4 / LEFTY2 Antibody - Western blot analysis of extracts of various cell lines, using LEFTY2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
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TGFB4 / LEFTY2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Viewing 1-25 of 63 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).