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TGFB2 / TGF Beta2

transforming growth factor, beta 2

TGFB2 / TGF Beta2 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: transforming growth factor, beta 2
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: TGFB2, BSC-1 cell growth inhibitor, Cetermin, G-TSF, LDS4, Polyergin, TGF-beta-2, TGF Beta2, TGF-beta2
Target Sequences: NM_003238 NP_003229.1 P61812

Publications (1)

1
Prolyl hydroxylase 2 silencing enhances the paracrine effects of mesenchymal stem cells on necrotizing enterocolitis in an NF-?B-dependent mechanism. Hao Chen , Haifeng Zhang , Yue Zheng , Xiaohui Min , Yujun Luo, Weijie Zhou, Faxin Ma, Jinliang Li, Quan Lu, Chen Zhang, Huihua Cai, Weihong Sha. Cell death & disease. 2020 Mar;11:188. [Full Text Article] [PubMed:32179740] [PMC:PMC7075868]

☰ Filters
Products
Proteins (19)
Over-Expression Lysate (4)
Recombinant (15)
TGFB2 / TGF Beta2 (19)
No (18)
Yes (1)
6His, N-terminus (1)
GST (1)
His (1)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Bovine (1)
Human (12)
Mouse (3)
Rat (1)
293T Cells (2)
CHO Cells (1)
E. coli (4)
HEK 293 Cells (4)
Human Cells (4)
Mammalian Cells (3)
Wheat Germ Extract (1)
Purified (5)
Low endotoxin level (9)
Biologically active (5)
TGFB2 / TGF Beta2 Protein
Select
E. coli
His
14.2 kDa
10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453
Select
HEK 293 Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
25.0 kDa
2 µg/$268; 10 µg/$349
TGFB2 / TGF Beta2 Protein - Recombinant Transforming Growth Factor Beta 2 By SDS-PAGE
Select
E. coli
His, N-Terminal
16.5 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
TGFB2 / TGF Beta2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
50.4 kDa
100 µg/$494
TGFB2 / TGF Beta2 Protein - Inhibition of IL-4 induce HT-2 cell proliferation by TGF-ß2.
Select
CHO Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 112 amino acid recombinant protein has a predicted molecular mass of approximately 12.7 kD. The DTT-reduced protein migrates at approximately 14 kD and non-reduced protein migrates at 28-30 kD by SDS-PAGE. The N-terminal amino acid is Alanine.
5 µg/$468
TGFB2 / TGF Beta2 Protein - 12.5% SDS-PAGE of human TGFB2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
74.1 kDa
2 µg/$439
TGFB2 / TGF Beta2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TGFB2 / TGF Beta2 Protein - Purified recombinant protein TGFB2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
47.6 kDa
20 µg/$1,107
TGFB2 / TGF Beta2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
50.4 kDa
20 µg/$150
TGFB2 / TGF Beta2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.6 kDa
20 µg/$150
TGFB2 / TGF Beta2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.6 kDa
100 µg/$494
Select
Mammalian Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.7 kDa
10 µg/$317; 50 µg/$524
Select
Mammalian Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.7 kDa
10 µg/$317; 50 µg/$524
Select
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.7kD
10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991
Select
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.7kD
10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991
Select
Human Cells
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
12.7 kDa
10 µg/$402; 1 mg/$3,780; 50 µg/$879
Select
Human Cells
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
12.7 kDa
10 µg/$402; 1 mg/$3,780; 50 µg/$879
TGFB2 / TGF Beta2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
12.7 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,932; 500 µg/$2,459
TGFB2 / TGF Beta2 Protein - Recombinant Transforming Growth Factor Beta 2 By SDS-PAGE
Select
E. coli
His-T7
16.7 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).