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TFF1 / pS2

trefoil factor 1

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. TFF1, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. The TFF1 gene consists of 3 exons, with exon 2 encoding the trefoil domain. The TFF1, TFF2, and TFF3 genes are located within a 55 kb region, suggesting they evolved from a common ancestor by duplication.

Gene Name: trefoil factor 1
Synonyms: TFF1, BCEI, D21S21, HPS2, PNR-2, Polypeptide P1.A, Protein pS2, PS2, HP1.A, Trefoil factor 1
Target Sequences: NM_003225 NP_003216.1 P04155

Publications (2)

1
Gastric TFF1 Expression from Acute to ChronicHelicobacterInfection. Esposito R, Morello S, Vllahu M, Eletto D, Porta A, Tosco A. Frontiers in cellular and infection microbiology. 2017 October;7:434. (Human) [Full Text Article] [PubMed:29085807] [PMC:PMC5649190] Related Antibodies: LS-C155659.
2
C/EBPa Epigenetically Modulates TFF1 Expression via mC-6 Methylation in the Jejunum Inflammation Induced by a Porcine Coronavirus. Huan Qu, Qiufang Zong, Haifei Wang, Shenglong Wu, Demin Cai, Wenbin Bao. Frontiers in immunology. 2022 June;13:881289. [Full Text Article] [PubMed:35693767] [PMC:PMC9174463] Related Antibodies: LS-C312842.

☰ Filters
Products
Proteins (19)
Over-Expression Lysate (2)
Recombinant (17)
TFF1 / pS2 (19)
No (19)
6His, N-terminus (1)
GST (2)
His (2)
His, C-Terminal (2)
His,C-terminus (2)
His-GST (2)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (13)
Mouse (4)
Rat (1)
293T Cells (1)
E. coli (10)
HEK 293 Cells (2)
Human (2)
Mammalian Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (4)
Low endotoxin level (6)
Biologically active (3)
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
8.3 kDa
10 µg/$277; 50 µg/$371
Select
E. coli
None
7.4 kDa
20 µg/$349; 5 µg/$268
TFF1 / pS2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
9.15 kDa
100 µg/$494
TFF1 / pS2 Protein - 12.5% SDS-PAGE of human TFF1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
34.98 kDa
10 µg/$479; 25 µg/$670
TFF1 / pS2 Protein
Select
E. coli
GST
34.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
Yeast
His
8.7 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
TFF1 / pS2 Protein - Recombinant Trefoil Factor 1 By SDS-PAGE
Select
E. coli
His-T7
12.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
TFF1 / pS2 Protein - Purified recombinant protein TFF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
6.6 kDa
20 µg/$1,107
TFF1 / pS2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
9.15 kDa
20 µg/$150
TFF1 / pS2 Protein
Select
E. coli
None
Biologically active
6.7 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
TFF1 / pS2 Protein
Select
E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
6.7 kDa
5 µg/$268; 20 µg/$349
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
7.5 kDa
10 µg/$277; 50 µg/$371
Select
E. coli
6His, N-terminus
10 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
7.5kD
10 µg/$277; 50 µg/$376; 500 µg/$1,484; 1 mg/$2,157
Select
Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
8.3kD
10 µg/$277; 50 µg/$376; 500 µg/$1,484; 1 mg/$2,157
TFF1 / pS2 Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~6.9 kDa
20 µg/$291; 100 µg/$597; 1 mg/$2,551
TFF1 / pS2 Protein - Recombinant Trefoil Factor 1 By SDS-PAGE
Select
E. coli
His-GST
41.6 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
TFF1 / pS2 Protein
Select
E. coli
His-GST
41.1 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Viewing 1-19 of 19 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).