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TFF1 / pS2
trefoil factor 1
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. TFF1, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. The TFF1 gene consists of 3 exons, with exon 2 encoding the trefoil domain. The TFF1, TFF2, and TFF3 genes are located within a 55 kb region, suggesting they evolved from a common ancestor by duplication.
| Gene Name: | trefoil factor 1 |
| Synonyms: | TFF1, BCEI, D21S21, HPS2, PNR-2, Polypeptide P1.A, Protein pS2, PS2, HP1.A, Trefoil factor 1 |
| Target Sequences: | NM_003225 NP_003216.1 P04155 |
Publications (2)
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