Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.
|Gene Name:||transcription factor EC|
|Synonyms:||TFEC, HTFEC-L, TFE-C, Transcription factor EC-like, BHLHe34, Transcription factor EC, TCFEC, TFEC-L, TFECL|
|Target Sequences:||NM_012252 NP_036384.1 O14948|
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