TFEB

transcription factor EB

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

TFEB (4)

Publications

No (4)

Tag

GST (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human TFEB Protein (Recombinant GST) (Full Length) - LS-G31040

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.1 kDa

Price:

2 µg/$439

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Human TFEB Protein (Recombinant His, N-Terminal) - LS-G144081

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

52.7 kDa

Price:

50 µg/$419

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TFEB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114832

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.7 kDa

Price:

100 µg/$494

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Human TFEB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79126

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.7 kDa

Price:

20 µg/$150

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