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TEX14
testis expressed 14
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro.
| Gene Name: | testis expressed 14 |
| Family/Subfamily: | Protein Kinase , NFK |
| Synonyms: | TEX14, SGK307, Sugen kinase 307, Testis expressed 14, Testis expressed sequence 14, Testis-expressed sequence 14, Cancer/testis antigen 113, CT113, Testis-expressed protein 14 |
| Target Sequences: | NM_031272 NP_112562.3 Q8IWB6 |
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