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TET2

tet methylcytosine dioxygenase 2

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Gene Name: tet methylcytosine dioxygenase 2
Synonyms: TET2, MDS, KIAA1546, Tet oncogene family member 2
Target Sequences: AB046766 BAB13372.1 Q6N021

Publications (2)

1
Decreased 5-hydroxymethylcytosine immunoreactivity in primary Merkel cell carcinoma is a strong predictor for disease-specific death. T Gambichler, K Schmitt, I Rüddel, M Dreibigacker, E Stockfleth, J C Becker. The British journal of dermatology. 2019 August;181:389-390. [Full Text Article] [PubMed:30703276] Related Antibodies: LS-C334211.
2
A study on DNA hydroxymethylation in Kaposi sarcoma and cutaneous angiosarcoma. T Gambichler, M Wrobel, S Koim, J C Becker, H U Käfferlein, T Brüning, K Lang. Journal of the European Academy of Dermatology and Venereology : JEADV. 2020 December;34:e785-e787. [Full Text Article] [PubMed:32279358] Related Antibodies: LS-C334211.

☰ Filters
Antibodies (24)
Primary (24)
TET2 (24)
Human (23)
Mouse (7)
Rat (4)
IHC (8)
IHC-P (5)
WB (21)
ELISA (12)
IF (1)
IP (1)
Peptide-ELISA (3)
rabbit (22)
goat (2)
IgG (17)
polyclonal pc (24)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (19)
aa528-554 (7)
aa1-156 (2)
aa100-150 (1)
aa1833-2002 (1)
aa254-267 (1)
aa761-775 (1)
No (23)
Yes (1)
TET2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TET2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TET2 Antibody - Detection of Human TET2 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-TET2 used at a dilution of 1:5000 (0.2 Detection: DAB.
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TET2 Rabbit anti-Human Polyclonal (aa100-150) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
TET2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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TET2 Rabbit anti-Human Polyclonal (aa1833-2002) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
TET2 Antibody - Western blot analysis of TET2 in 3T3 cell lysate with TET2 antibody at 1 ug/ml.
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TET2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$460
TET2 Antibody - Immunohistochemistry of TET2 in human colon carcinoma tissue with TET2 antibody at 2 µg/ml.
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TET2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
Select
TET2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
TET2 Antibody
Select
TET2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
TET2 Antibody - 1:100 staining mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TET2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
TET2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
Select
TET2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
TET2 Rabbit anti-Human Polyclonal (aa528-554) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
TET2 Rabbit anti-Human Polyclonal (aa528-554) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
TET2 Rabbit anti-Human Polyclonal (aa528-554) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
TET2 Rabbit anti-Human Polyclonal (aa528-554) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
TET2 Rabbit anti-Human Polyclonal (aa528-554) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
TET2 Rabbit anti-Human Polyclonal (aa528-554) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
TET2 Antibody - Western Blot of rabbit Anti-Tet2 Antibody. Lane 1: Whole Cell Extract. Lane 2: Cytosolic Extract. Lane 3: Nuclear Extract. Lane 4: Chromatin Fraction. Load: 35 µg per lane. Primary antibody: TET2 antibody at 1:5000 for 5 hours at room temperature. Secondary antibody: HRP rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: ~230 and ~150kDa. Other band(s): nonspecific.
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TET2 Rabbit anti-Human Polyclonal (aa1-156) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$567
TET2 Antibody - Western Blot of rabbit Anti-Tet2 Antibody. Lane 1: Whole Cell Extract. Lane 2: Cytosolic Extract. Lane 3: Nuclear Extract. Lane 4: Chromatin Fraction. Load: 35 µg per lane. Primary antibody: TET2 antibody at 1:5000 for 5 hours at room temperature. Secondary antibody: HRP rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: ~230 and ~150kDa. Other band(s): nonspecific.
Select
TET2 Rabbit anti-Human Polyclonal (aa1-156) Antibody
Human
ELISA, WB
Unconjugated
25 µl/$304
TET2 Antibody - Goat Anti-TET2  Antibody (4µg/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
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TET2 Goat anti-Human Polyclonal (aa761-775) Antibody
Human
IHC-P, Peptide-ELISA
Unconjugated
100 µg/$503
Select
TET2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
Select
TET2 Goat anti-Mouse Polyclonal (aa254-267) Antibody
Mouse, Rat
Peptide-ELISA
Unconjugated
100 µg/$467
TET2 Antibody - TET2 Antibody western blot of A549 cell line lysates (35 ug/lane). The TET2 antibody detected the TET2 protein (arrow).
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TET2 Rabbit anti-Human Polyclonal (aa528-554) Antibody
Human
WB
Unconjugated
400 µl/$393
TET2 Antibody - Western blot analysis of extracts of A549 cell line, using TET2 antibody.
Select
TET2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TET2 Antibody - Western blot analysis of extracts of mouse heart, using TET2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.
Select
TET2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Viewing 1-24 of 24 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).