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Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development By similarity. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release and mitochondrial Ca2+ uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.
Gene Name: | thymocyte expressed, positive selection associated 1 |
Synonyms: | TESPA1, HSPC257, KIAA0748, Protein TESPA1 |
Target Sequences: | AB018291 BAA34468.2 A2RU30 |
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