TERT / Telomerase

telomerase reverse transcriptase

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

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Products

Proteins (6)

Type

Over-Expression Lysate (1)

Recombinant (5)

Target

TERT / Telomerase (6)

Publications

No (6)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

His (1)

His-GST (1)

His-GST, N-terminus (1)

Myc-DDK (Flag) (1)

Species

Human (2)

Mouse (2)

Rat (1)

Source

E. coli (5)

HEK 293 Cells (1)

Purification

Purified (2)

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Human TERT / Telomerase Protein (Recombinant His-GST) (aa787-1084) - LS-G14856

Source:

E. coli

Tag:

His-GST

Molecular Weight:

65.8 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human TERT / Telomerase Protein (Recombinant 6His, N-terminus) (aa281-436) - LS-G56567

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,486; 100 µg/$451; 20 µg/$339

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Mouse TERT / Telomerase Protein (Recombinant His-GST, N-terminus) (Gln642-Lys974) - LS-G14855

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

67.4 kDa

Price:

10 µg/$285; 50 µg/$465; 100 µg/$742; 200 µg/$930; 1 mg/$2,052; 500 µg/$1,586; 5 mg/$3,249; 2 mg/$2,241

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Mouse TERT / Telomerase Protein (Recombinant 6His-SUMO, N-terminus) (aa595-928) - LS-G56570

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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TERT / Telomerase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102557

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.8 kDa

Price:

100 µg/$710

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Rat TERT / Telomerase Protein (Recombinant His) (aa673-976) - LS-G14860

Source:

E. coli

Tag:

His

Molecular Weight:

35.8 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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