TERF2IP / RAP1

telomeric repeat binding factor 2, interacting protein

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

TERF2IP / RAP1 (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human TERF2IP / RAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86387

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

20 µg/$150

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Human TERF2IP / RAP1 Protein (Recombinant GST) (Full Length) - LS-G33962

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.7 kDa

Price:

10 µg/$479; 25 µg/$670

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TERF2IP / RAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101605

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

100 µg/$494

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