TEAD4

TEA domain family member 4

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

TEAD4 (8)

Publications

No (8)

Tag

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-SUMO (1)

Myc-DDK (Flag) (4)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human TEAD4 Protein (Recombinant 6His-SUMO, N-terminus) (aa74-434) - LS-G56704

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human TEAD4 Protein (Recombinant GST, N-terminus) (aa151-260) - LS-G60312

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TEAD4 Protein (Recombinant His-SUMO) (aa74-434) - LS-G21666

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

56.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human TEAD4 Protein (Recombinant GST) (Full Length) - LS-G30665

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

65.45 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TEAD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79262

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

20 µg/$150

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Human TEAD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79263

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.3 kDa

Price:

20 µg/$215

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TEAD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117483

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.3 kDa

Price:

100 µg/$710

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TEAD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103198

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

100 µg/$494

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