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Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
|Gene Name:||TEA domain family member 3|
|Synonyms:||TEAD3, DTEF-1, ETFR-1, TEA domain family member 3, TEA domain family member 5, TEAD-3, TEAD5, TEF-5, TEF5|
|Target Sequences:||NM_003214 NP_003205.2 Q99594|
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