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TDP1
tyrosyl-DNA phosphodiesterase 1
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
| Gene Name: | tyrosyl-DNA phosphodiesterase 1 |
| Synonyms: | TDP1, Tyr-DNA phosphodiesterase 1, SCAN1 |
| Target Sequences: | NM_018319 NP_060789.2 Q9NUW8 |
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