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TDO2

tryptophan 2,3-dioxygenase

TDO2 is a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Gene Name:	tryptophan 2,3-dioxygenase
Synonyms:	TDO2, TDO, TO, TRPO, Tryptophan pyrrolase, Tryptophan oxygenase, Tryptophan 2,3-dioxygenase, Tryptophanase, Tryptamin 2,3-dioxygenase
Target Sequences:	NM_005651 NP_005642.1 P48775

Publications (4)

Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma. Masaki A, Ishida T, Maeda Y, Suzuki S, Ito A, Takino H, Ogura H, Totani H, Yoshida T, Kinoshita S, Narita T, Ri M, Kusumoto S, Inagaki A, Komatsu H, Niimi A, Ueda R, Utsunomiya A, Inagaki H, Iida S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:2830-9. (IHC, IF; Human) [Full Text Article] [PubMed:25788494] Related Antibodies: LS-C174023.

Restoration of energy homeostasis by SIRT6 extends healthy lifespan. A Roichman , S Elhanati , M A Aon, I Abramovich, A Di Francesco, Y Shahar, M Y Avivi, M Shurgi, A Rubinstein, Y Wiesner, A Shuchami, Z Petrover, I Lebenthal-Loinger, O Yaron, A Lyashkov, C Ubaida-Mohien, Y Kanfi, B Lerrer, P J Fernández-Marcos, M Serrano, E Gottlieb, R de Cabo, H Y Cohen. Nature communications. 2021 May;12:3208. [Full Text Article] [PubMed:34050173] [PMC:PMC8163764] Related Antibodies: LS-C748245.

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma. Mizue Terai, Eric Londin, Ankit Rochani, Emma Link, Bao Lam, Gagan Kaushal, Alok Bhushan, Marlana Orloff, Takami Sato. Cancers. 2020 Feb;12:405. [Full Text Article] [PubMed:32050636] [PMC:PMC7072257] Related Antibodies: LS-B5791.

The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat. Nagy-Grócz G, Laborc KF, Veres G, Bajtai A, Bohár Z, Zádori D, Fejes-Szabó A, Spekker E, Vécsei L, Párdutz Ã. Frontiers in neurology. 2017 8:278. (WB; Rat) [Full Text Article] [PubMed:28659861] [PMC:PMC5469907] Related Antibodies: LS-C111058.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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