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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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TDGF1 / CRIPTO
teratocarcinoma-derived growth factor 1
TDGF1, also called Cripto-1, is an epidermal growth factor (EGF)-related protein required during mesoderm development. Null mutations in mice are embryonic lethal due to defects in precardiac mesoderm, no cardiomyocyte differentiation and poor neural tube and head-fold morphogenesis. In adult, TDGF1 mutations lead to aberrant morphology of the mammary gland with consequences during lactation. TDGF1 is highly expressed in breast (80%), colon (80%), ovarian, uterine, gastric, pancreatic and bladder tumors and may be a useful marker for the corresponding malignancies.
| Gene Name: | teratocarcinoma-derived growth factor 1 |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | TDGF1, CRGF, Cripto-1 growth factor, CR, CRIPTO, Cripto-1 |
| Target Sequences: | NM_003212 NP_003203.1 P13385 |
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