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TCF7
transcription factor 7 (T-cell specific, HMG-box)
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
| Gene Name: | transcription factor 7 (T-cell specific, HMG-box) |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | TCF7, TCF-7, TCF1, Transcription factor 7, T-cell factor 1, TCF-1 |
| Target Sequences: | NM_003202 NP_003193.2 P36402 |
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