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TCF4

transcription factor 4

TCF4 encodes transcription factor 4, a basic helix-turn-helix transcription factor. The protein recognizes an Ephrussi-box (&#039E-box&#039) binding site (&#039CANNTG&#039) - a motif first identified in immunoglobulin enhancers. TCF4 is expressed predominantly in pre-B-cells, although it is found in other tissues as well. TCF4 is known to produce multiple transcripts; however as the complete structure is only known for the transcript that encodes the b isoform, that is the variant presented here.

Gene Name: transcription factor 4
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: TCF4, BHLHb19, E2-2, ITF-2, ITF2, PTHS, SEF2-1B, SEF2-1, SEF2-1A, SL3-3 enhancer factor 2, SEF2, SEF-2, TCF-4, Transcription factor 4
Target Sequences: NM_003199 NP_003190.1 P15884

Publications (2)

1
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Afshari NA, Igo RP Jr, Morris NJ, Stambolian D, Sharma S, Pulagam VL, Dunn S, Stamler JF, Truitt BJ, Rimmler J, Kuot A, Croasdale CR, Qin X, Burdon KP, Riazuddin SA, Mills R, Klebe S, Minear MA, Zhao J, Balajonda E, Rosenwasser GO, Baratz KH, Mootha VV, Patel SV, Gregory SG, Bailey-Wilson JE, Price MO, Price FW Jr, Craig JE, Fingert JH, Gottsch JD, Aldave AJ, Klintworth GK, Lass JH, Li YJ, Iyengar SK. Nature communications. 2017 8:14898. (IHC; Human) [Full Text Article] [PubMed:28358029] [PMC:PMC5379100] Related Antibodies: LS-B1570.
2
Primary fibroblasts of NDUFS4(-/-) mice display increased ROS levels and aberrant mitochondrial morphology. Valsecchi F, Grefte S, Roestenberg P, Joosten-Wagenaars J, Smeitink JA, Willems PH, Koopman WJ. Mitochondrion. 2013 Sep;13:436-43. [Full Text Article] [PubMed:23234723] Related Antibodies: LS-B1570.

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Proteins (9)
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TCF4 (9)
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TCF4 Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
TCF4 Protein - Purified recombinant protein TCF4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
71.6 kDa
20 µg/$1,107
TCF4 Protein - Purified recombinant protein TCF4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
71.1 kDa
20 µg/$1,107
TCF4 Protein - 12.5% SDS-PAGE of human TCF4 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.89 kDa
10 µg/$479; 25 µg/$670
TCF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
71.1 kDa
100 µg/$710
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E. coli
His, N-Terminal
71.1 kDa
50 µg/$419
TCF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
71.6 kDa
20 µg/$215
TCF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
71.1 kDa
20 µg/$215
TCF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
71.6 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).