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TCAB1 / WDR79
WD repeat containing, antisense to TP53
Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.
| Gene Name: | WD repeat containing, antisense to TP53 |
| Synonyms: | WRAP53, DKCB3, WDR79, TCAB1, WD repeat domain 79, WD40 protein Wrap53 |
| Target Sequences: | NM_018081 NP_060551.2 Q9BUR4 |
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