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TBX21 / T-bet
T-box 21
TBX21 / T-bet is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
| Gene Name: | T-box 21 |
| Synonyms: | TBX21, T-bet, TBET, T-box 21, T-box protein 21, TBLYM, Transcription factor TBLYM, T-box expressed in T cells, T-PET |
| Target Sequences: | NM_013351 NP_037483.1 Q9UL17 |
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