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TBCD
tubulin folding cofactor D
Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
| Gene Name: | tubulin folding cofactor D |
| Synonyms: | TBCD, Beta-tubulin cofactor D, Tubulin folding cofactor D, Tubulin-folding cofactor D, Tubulin-specific chaperone D, SSD-1, SSD1, TfcD, KIAA0988 |
| Target Sequences: | NM_005993 NP_005984.3 Q9BTW9 |
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