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TBCA
tubulin folding cofactor A
TBCA is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | tubulin folding cofactor A |
| Synonyms: | TBCA, Chaperonin cofactor A, CFA, Co-chaperonin 'cofactor a', Tubulin-specific chaperone A, Tubulin-folding cofactor A, TCP1-chaperonin cofactor A, Tubulin folding cofactor A |
| Target Sequences: | NM_004607 NP_004598.1 O75347 |
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