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Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Gene Name: | TBC1 Domain Family, Member 7 |
Synonyms: | TBC1D7, DJ257A7.3, TCD1D7, TBC7, PIG51, TBC1 domain family member 7, TBC1 domain family, member 7 |
Target Sequences: | NM_016495 NP_057579.1 Q9P0N9 |
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