Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
|Gene Name:||chromatin assembly factor 1, subunit A (p150)|
|Synonyms:||CHAF1A, CAF-I p150, CAF1P150, CAF-1 subunit A, CAF-1, Hp150, p150, CAF, CAF-I 150 kDa subunit, CAF1, CAF1B|
|Target Sequences:||NM_005483 NP_005474.2 Q13111|
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