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CHAF1A / CAF1

chromatin assembly factor 1, subunit A (p150)

Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Gene Name: chromatin assembly factor 1, subunit A (p150)
Synonyms: CHAF1A, CAF-I p150, CAF1P150, CAF-1 subunit A, CAF-1, Hp150, p150, CAF, CAF-I 150 kDa subunit, CAF1, CAF1B
Target Sequences: NM_005483 NP_005474.2 Q13111

Publications (6)

1
Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. Shibahara K, Stillman B. Cell. 1999 96:575-85. [PubMed:10052459]
2
Local action of the chromatin assembly factor CAF-1 at sites of nucleotide excision repair in vivo. Green CM, Almouzni G. The EMBO journal. 2003 22:5163-74. [PubMed:14517254] [PMC:PMC204462]
3
Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1. Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li JL, Egli D, Hickson ID, Stagljar I. Molecular and cellular biology. 2004 24:4710-9. [PubMed:15143166] [PMC:PMC416397]
4
Proliferating cell nuclear antigen (PCNA) may function as a double homotrimer complex in the mammalian cell. Naryzhny SN, Zhao H, Lee H. The Journal of biological chemistry. 2005 280:13888-94. [PubMed:15805117]
5
Hsp60 regulation of tumor cell apoptosis. Ghosh JC, Dohi T, Kang BH, Altieri DC. The Journal of biological chemistry. 2008 283:5188-94. [PubMed:18086682]
6
In vivo study of the nucleosome assembly functions of ASF1 histone chaperones in human cells. Galvani A, Courbeyrette R, Agez M, Ochsenbein F, Mann C, Thuret JY. Molecular and cellular biology. 2008 28:3672-85. [PubMed:18378699] [PMC:PMC2423286]
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☰ Filters
Antibodies (27)
Proteins (4)
Over-Expression Lysate (2)
Primary (27)
Recombinant (2)
CHAF1A / CAF1 (31)
Human (27)
Mouse (3)
Rat (1)
IHC (6)
IHC-P (3)
WB (21)
DB (1)
ELISA (15)
ICC (1)
IF (1)
IP (3)
rabbit (16)
mouse (11)
Product Group
IHCPlus (1)
IgG (11)
IgG1 (4)
IgG2b,k (7)
monoclonal mc (11)
polyclonal pc (16)
2168C3a (1)
p150-48 (1)
SS 1 1-13 (1)
AP Conjugated (1)
APC Conjugated (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (15)
C-Terminus (4)
300-380 aa, Internal (1)
aa100-150 (1)
aa21-120 (1)
aa500-550 (1)
No (31)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
CHAF1A / CAF1 Antibody - Anti-CHAF1A antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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CHAF1A / CAF1 Mouse anti-Human Monoclonal (SS 1 1-13) Antibody
Human
IHC, IHC-P
Unconjugated
50 µl/$460
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$376
CHAF1A / CAF1 Antibody
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CHAF1A / CAF1 Mouse anti-Human Monoclonal (p150-48) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$381
CHAF1A / CAF1 Antibody - Detection of Human Caf1p150 by Immunohistochemistry. Sample: FFPE section of human colon carcinoma Peyer's patch. Antibody: Affinity purified rabbit anti-Caf1p150 used at a dilution of 1:200 (1 ug/ml).
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal (aa500-550) Antibody
Human
IHC, IP, WB
Unconjugated
100 µl/$457
CHAF1A / CAF1 Antibody - Detection of Human Caf1p150 by Immunohistochemistry. Sample: FFPE section of human colon carcinoma Peyer's patch. Antibody: Affinity purified rabbit anti-Caf1p150 used at a dilution of 1:200 (1 ug/ml).
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal (aa100-150) Antibody
Human
IHC, IP, WB
Unconjugated
100 µl/$457
CHAF1A / CAF1 Antibody - Immunohistochemistry Dilution at 1:400 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$284; 100 µg/$351
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$284; 100 µg/$351
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$284; 100 µg/$351
Select
CHAF1A / CAF1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$284; 100 µg/$351
CHAF1A / CAF1 Antibody - Western blot analysis of CAF1A expression in rat brain lysate
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$369; 200 µl/$411
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CHAF1A / CAF1 Mouse anti-Human Monoclonal (aa21-120) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$582
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CHAF1A / CAF1 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$734
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CHAF1A / CAF1 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$734
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CHAF1A / CAF1 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$734
Select
CHAF1A / CAF1 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$734
Select
CHAF1A / CAF1 Mouse anti-Human Monoclonal (AP) Antibody
Human
ELISA, WB
AP Conjugated
100 µl/$734
Select
CHAF1A / CAF1 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$734
CHAF1A / CAF1 Antibody - Western blot of CAF-1 p150 antibody
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal (300-380 aa, Internal) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
CHAF1A / CAF1 Antibody - Western blot of extracts from K562 cells and A549 cells, using CAF1A antibody.
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$347
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CHAF1A / CAF1 Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µg/$611
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CHAF1A / CAF1 Mouse anti-Human Monoclonal (2168C3a) Antibody
Human
DB
Unconjugated
100 µg/$557
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
60 µl/$278; 120 µl/$338; 200 µl/$440
CHAF1A / CAF1 Antibody - Western blot of CAF1A Antibody with human HepG2 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$434
CHAF1A / CAF1 Antibody - Western blot of CAF1A Antibody with human HepG2 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$459
CHAF1A / CAF1 Antibody - Western blot analysis of extracts of various cell lines, using CHAF1A antibody.
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CHAF1A / CAF1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
Viewing 1-25 of 31 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).