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CD59

CD59 molecule, complement regulatory protein

CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Gene Name: CD59 molecule, complement regulatory protein
Synonyms: CD59, 16.3A5, 1F5, 1F5 antigen, CD59 glycoprotein, EL32, EJ16, G344, HRF-20, MAC-IP, MACIF, Ly-6-like protein, MEM43, MIRL, MEM43 antigen, MIN2, MIN3, MSK21, p18-20, Protectin, MAC-inhibitory protein, MIC11, T cell-activating protein, CD59 antigen, EJ30, HRF20, Human leukocyte antigen MIC11, Lymphocytic antigen CD59/MEM43, MIN1
Target Sequences: NM_000611 NP_000602.1 P13987

Publications (4)

1
Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59. Zhang H, Verkman AS. Journal of autoimmunity. 2014 53:67-77. (WB; Mouse) [Full Text Article] [PubMed:24698947] [PMC:PMC4162764]
2
A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia. Christopher J Peters, Jonathan R E Rees, Richard H Hardwick, James S Hardwick, Sarah L Vowler, Chin-Ann J Ong, Chunsheng Zhang, Vicki Save, Maria O'Donovan, Doris Rassl, Derek Alderson, Carlos Caldas, Rebecca C Fitzgerald, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group. Gastroenterology. 2010 December;139:1995-2004.e15. [Full Text Article] [PubMed:20621683] Related Antibodies: LS-B1852.
3
CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica. Lukmanee Tradtrantip, Tianjiao Duan, Michael R Yeaman, Alan S Verkman. Journal of neuroinflammation. 2019 March;16:57. [Full Text Article] [PubMed:30851734] [PMC:PMC6408857] Related Antibodies: LS-C209613.
4
Protective responses to sublytic complement in the retinal pigment epithelium. Li Xuan Tan, Kimberly A Toops, Aparna Lakkaraju. Proceedings of the National Academy of Sciences of the United States of America. 2016 August;113:8789-94. [Full Text Article] [PubMed:27432952] [PMC:PMC4978296]
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CD59 Antibody - Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer
CD59 Mouse anti-Human Monoclonal (MEM-43) Antibody
Human
Flo, Func, IHC, IHC-P, IP
Unconjugated
0.05 mg/$440
CD59 Antibody - Anti-CD59 antibody IHC of human skin, pilosebaceous unit. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Cancer
CD59 Mouse anti-Human Monoclonal (MEM-43/5) Antibody
Mouse, Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
CD59 Antibody - Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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CD59 Mouse anti-Human Monoclonal (1F5) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
50 µg/$460
CD59 Antibody - Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CD59 Mouse anti-Human Monoclonal (p282(H19)) Antibody
Human, Monkey, Baboon
Flo, IHC, IHC-P
Unconjugated
50 µg/$440
CD59 Antibody - IHC of paraffin-embedded bladder cancer tissues using CD59 mouse monoclonal antibody with DAB staining.
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CD59 Mouse anti-Human Monoclonal (8D2B8) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
0.1 mg/$426
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CD59 Mouse anti-Human Monoclonal (Preservative Free) (MEM-43) Antibody
Human
ELISA, Flo, IF, IHC-Fr, IHC-P, IP, WB
Unconjugated, Preservative Free
1 mg/$913
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CD59 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo
Biotin Conjugated
100 µg/$533
CD59 Antibody - Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CD59 Rabbit Recombinant Monoclonal Antibody (MACIF/2867R).
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CD59 Rabbit anti-Human Recombinant Monoclonal (Azide-free, Carrier-free) (MACIF/2867R) Antibody
Human
IHC-P
Unconjugated, Azide-free, Carrier-free
100 µg/$550
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CD59 Mouse anti-Rat Monoclonal (TH9) Antibody
Rat
Flo, Func, IHC, IHC-Fr, WB
Unconjugated
100 µg/$644
CD59 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$792
CD59 Antibody - Anti-CD59 antibody IHC of human skin, sweat glands. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CD59 Mouse anti-Human Monoclonal (MEM-43) Antibody
Human
ELISA, Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$460
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CD59 Mouse anti-Mouse Monoclonal (FITC) (7A6) Antibody
Mouse
Flo, Func, IF, IHC, IHC-Fr, WB
FITC Conjugated
100 µg/$556
Select
CD59 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$284; 100 µg/$348
CD59 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
CD59 Antibody - Western blot of recombinant CD59.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD59 Rabbit anti-Pig Polyclonal (aa26-98) Antibody
Pig
WB
Unconjugated
100 µl/$275; 200 µl/$360; 500 µl/$519; 1 ml/$614
Select
Yeast
6His, N-terminus
11 kD
1 mg/$1,342; 100 µg/$436; 20 µg/$324
CD59 Antibody - Western blot of recombinant CD59.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD59 Rabbit anti-Human Polyclonal (aa26-102) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$301; 200 µl/$347; 500 µl/$493; 1 ml/$566
CD59 Antibody - Anti-CD59 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD59 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IHC, IHC-P
FITC Conjugated
60 Tests/$505
CD59 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using CD59 Polyclonal Antibody at dilution of 1:50.
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CD59 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$242; 60 µl/$284; 120 µl/$343; 200 µl/$451
CD59 Antibody - Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
CD59 Mouse anti-Human Monoclonal (Low Endotoxin) Antibody
Human
Flo, IHC, IHC-P, IP, WB
Unconjugated, Low Endotoxin
50 µg/$485
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CD59 Rabbit anti-Human Monoclonal (Preservative Free) (015) Antibody
Human
ELISA
Unconjugated, Preservative Free
50 µl/$290; 100 µl/$350; 1 ml/$1,001
Select
CD59 Rabbit anti-Human Monoclonal (Preservative Free) (031) Antibody
Human
ELISA
Unconjugated, Preservative Free
50 µl/$290; 100 µl/$350; 1 ml/$1,001
Select
CD59 Mouse anti-Human Monoclonal (MEM-43) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$547; 200 µg/$742
Select
CD59 Rat anti-Human Monoclonal (YTH53.1) Antibody
Human
Flo, IHC, IHC-Fr, WB
Unconjugated
0.2 mg/$444
CD59 Antibody - Immunohistochemical of paraffin-embedded Human breast cancer using CD59 Monoclonal Antibody (2E11-2B5) at dilution of 1:200.
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CD59 Mouse anti-Human Monoclonal (2E11B6) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$306; 100 µg/$376
Viewing 1-25 of 253 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).