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FTH1 / Ferritin Heavy Chain

ferritin, heavy polypeptide 1

FTH1 / Ferritin Heavy Chain is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Gene Name: ferritin, heavy polypeptide 1
Synonyms: FTH1, Apoferritin, Ferritin H subunit, Ferritin heavy chain, Ferritin, heavy polypeptide 1, FHC, FTHL6, PIG15, PLIF, FTH
Target Sequences: NM_002032 NP_002023.2 P02794

Publications (7)

1
Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by mutation. Hasan MR, Tosha T, Theil EC. The Journal of biological chemistry. 2008 283:31394-400. [PubMed:18805796] [PMC:PMC2581568]
2
Redox control of iron regulatory protein 2 stability. Hausmann A, Lee J, Pantopoulos K. FEBS letters. 2011 585:687-92. [PubMed:21281640]
3
Alternative ferritin mRNA translation via internal initiation. Daba A, Koromilas AE, Pantopoulos K. RNA (New York, N.Y.). 2012 18:547-56. [PubMed:22271759] [PMC:PMC3285941]
4
Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment. Song W, Zukor H, Lin SH, Liberman A, Tavitian A, Mui J, Vali H, Fillebeen C, Pantopoulos K, Wu TD, Guerquin-Kern JL, Schipper HM. Journal of neurochemistry. 2012 123:325-36. (WB; Mouse) [PubMed:22881289]
5
Iron deposition and ferritin heavy chain (Fth) localization in rodent teeth. Wen X, Paine ML. BMC research notes. 2013 6:1. (IHC-P; Mouse, Rat) [Full Text Article] [PubMed:23281703] [PMC:PMC3556315] Related Antibodies: LS-B5847.
6
Reabsorption of iron into acutely damaged rat liver: A role for ferritins. Malik IA, Wilting J, Ramadori G, Naz N. World journal of gastroenterology : WJG. 2017 November;23:7347-7358. (Human) [Full Text Article] [PubMed:29151689] [PMC:PMC5685841]
7
Ferritin in glioblastoma. Heidi Jaksch-Bogensperger , Sabine Spiegl-Kreinecker, Paolo Arosio, Peter Eckl, Stefan Golaszewski, Yvonne Ebner, Rahman Al-Schameri, Peter Strasser, Serge Weis , Nikolaus Bresgen. British journal of cancer. 2020 May;122:1441-1444. [Full Text Article] [PubMed:32203223] [PMC:PMC7217840]
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Antibodies (112)
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FTH1 / Ferritin Heavy Chain (214)
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FTH1 / Ferritin Heavy Chain Antibody - Anti-FTH1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal (aa110-159) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$485
FTH1 / Ferritin Heavy Chain Antibody - Anti-Ferritin Heavy Chain / FTH1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal (aa154-183) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$515
FTH1 / Ferritin Heavy Chain Antibody - Anti-FTH1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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FTH1 / Ferritin Heavy Chain Mouse anti-Human Monoclonal (3F8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$485
FTH1 / Ferritin Heavy Chain Antibody - Anti-FTH1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
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FTH1 / Ferritin Heavy Chain Goat anti-Human Polyclonal (aa221-232) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$585
FTH1 / Ferritin Heavy Chain ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$821
FTH1 / Ferritin Heavy Chain ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
FTH1 / Ferritin Heavy Chain ELISA Kit
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Sandwich
96-Well Microplate
Human
12.5 - 800 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$654
FTH1 / Ferritin Heavy Chain Protein - Recombinant Ferritin, Heavy Polypeptide By SDS-PAGE
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E. coli
His, N-Terminal
22.6 kDa
10 µg/$262; 50 µg/$365; 100 µg/$581; 200 µg/$727; 1 mg/$1,681
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal Antibody
Chicken, Bovine, Mouse, Rat, Human, Monkey
ELISA, WB
Unconjugated
100 µl/$740
FTH1 / Ferritin Heavy Chain Antibody
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal (aa1-183) Antibody
Human
ELISA, IHC
Unconjugated
100 µl/$309
FTH1 / Ferritin Heavy Chain ELISA Kit
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Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$889
FTH1 / Ferritin Heavy Chain Antibody - Immunohistochemistry of paraffin-embedded human liver cancer tissue.
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
FTH1 / Ferritin Heavy Chain Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
100 µg/$289; 500 µg/$478; 1 mg/$717
FTH1 / Ferritin Heavy Chain ELISA Kit
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Sandwich
96-Well Microplate
Mouse
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$654
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
21.2kD
10 µg/$236; 50 µg/$274; 500 µg/$702; 1 mg/$1,047
FTH1 / Ferritin Heavy Chain Protein - Recombinant Ferritin, Heavy Polypeptide By SDS-PAGE
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E. coli
His-T7
25.0 kDa
10 µg/$271; 50 µg/$422; 100 µg/$674; 200 µg/$841; 1 mg/$1,880
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal (aa154-183) Antibody
Human
Flo, IHC, WB
Unconjugated
200 µl/$614
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal (aa154-183) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$767
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal (aa154-183) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$767
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal (aa154-183) (AP) Antibody
Human
ELISA, Flo, IHC, WB
AP Conjugated
200 µl/$767
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal (aa154-183) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$767
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$284; 100 µg/$351
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$284; 100 µg/$351
FTH1 / Ferritin Heavy Chain Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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FTH1 / Ferritin Heavy Chain Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
Viewing 1-25 of 214 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).