Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

OAS1

2'-5'-oligoadenylate synthetase 1, 40/46kDa

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

Gene Name: 2'-5'-oligoadenylate synthetase 1, 40/46kDa
Synonyms: OAS1, 2,5-oligo A synthetase 1, 2-5A synthetase 1, 2-5A synthase 1, 2-5-oligoadenylate synthase 1, E18/E16, OIASI, OIAS, p46/p42 OAS, IFI-4
Target Sequences: NM_016816 NP_058132.2 P00973

Publications (3)

1
Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:1828-33. [PubMed:16446426] [PMC:PMC1413670] Related Antibodies: LS-C100473.
2
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L. Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ. Journal of virology. 2007 81:5561-72. [PubMed:17344297] [PMC:PMC1900262] Related Antibodies: LS-C100473.
3
Azithromycin induces anti-viral responses in bronchial epithelial cells. Gielen V, Johnston SL, Edwards MR. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2010 36:646-54. [PubMed:20150207] Related Antibodies: LS-C100473.

Viewing 1-25 of 55 items
OAS1 Antibody - Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human OAS1
Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human OAS1
Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $405.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human OAS1
Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $405.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human OAS1
Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $405.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human OAS1
Rabbit, Mouse, Dog, Bovine, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $385.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $385.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $405.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $405.00
OAS1 Antibody - Anti-OAS1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $405.00
OAS1 Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human OAS1
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
OAS1 Antibody
Select
Rabbit Polyclonal to Human OAS1
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human
ELISA, IHC, WB
Unconjugated
100µg   $335.00
OAS1 Antibody
Select
Rabbit Polyclonal to Human OAS1
Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $265.00
OAS1 Antibody - Immunohistochemistry of paraffin-embedded human liver tissue at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human OAS1
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human OAS1
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human OAS1
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human OAS1
Mouse, Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human OAS1
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human OAS1
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human OAS1
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human OAS1
Mouse, Human
IF, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00

Viewing 1-25 of 55 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).