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CKAP5 / ch-TOG

cytoskeleton associated protein 5

CKAP5 / ch-TOG is a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: cytoskeleton associated protein 5
Synonyms: CKAP5, CKAP-5, CHTOG, Ch-TOG, TOGp, KIAA0097, MSPS, TOG
Target Sequences: X92474 Q14008 Q14008

Publications (4)

1
ch-TOGp is required for microtubule aster formation in a mammalian mitotic extract. Dionne MA, Sanchez A, Compton DA. The Journal of biological chemistry. 2000 275:12346-52. (Human) [PubMed:10766876]
2
Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity. Appierto V, Tiberio P, Cavadini E, Casalini P, Cappelletti G, Formelli F. Molecular cancer therapeutics. 2009 8:3360-8. [PubMed:19996280]
3
Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corra IR, Doxsey SJ, Brodsky FM. The Journal of cell biology. 2012 198:591-605. [PubMed:22891263] [PMC:PMC3514040]
4
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S. Oncogene. 2011 30:521-34. (WB) [Full Text Article] [PubMed:20838383]
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☰ Filters
Antibodies (13)
Primary (13)
CKAP5 / ch-TOG (13)
Human (13)
Mouse (5)
Rat (4)
Bovine (1)
Chicken (1)
Chimpanzee (1)
Dog (1)
Frog (1)
Mammal (1)
Opossum (1)
IHC (2)
IHC-P (3)
WB (9)
ELISA (1)
IF (3)
IP (4)
rabbit (13)
Product Group
IHCPlus (2)
IgG (9)
polyclonal pc (13)
AP Conjugated (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (9)
C-Terminus (2)
aa1425-1475 (1)
aa1982-2032 (1)
aa875-925 (1)
No (13)
CKAP5 / ch-TOG Antibody - Anti-CKAP5 / ch-TOG antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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CKAP5 / ch-TOG Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Mammal, Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
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CKAP5 / ch-TOG Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IF, IP, WB
Unconjugated
100 µl/$649
CKAP5 / ch-TOG Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CKAP5 / ch-TOG Rabbit anti-Human Polyclonal Antibody
Frog, Chicken, Bovine, Mouse, Dog, Opossum, Rat, Chimpanzee, Human
IF, IHC-P, IP, WB
Unconjugated
50 µl/$460
CKAP5 / ch-TOG Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal (aa875-925) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal (aa1982-2032) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal (aa1425-1475) Antibody
Human
WB
Unconjugated
10 µl/$295; 100 µl/$514
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CKAP5 / ch-TOG Antibody
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
CKAP5 / ch-TOG Antibody - Western blot analysis of extracts of various cells.
Select
CKAP5 / ch-TOG Rabbit anti-Human Polyclonal (AP) Antibody
Mouse, Rat, Human
WB
AP Conjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Viewing 1-13 of 13 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).