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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CKAP5 / ch-TOG

cytoskeleton associated protein 5

CKAP5 / ch-TOG is a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: cytoskeleton associated protein 5
Synonyms: CKAP5, CKAP-5, CHTOG, Ch-TOG, TOGp, KIAA0097, MSPS, TOG
Target Sequences: X92474 Q14008 Q14008

Publications (4)

1
ch-TOGp is required for microtubule aster formation in a mammalian mitotic extract. Dionne MA, Sanchez A, Compton DA. The Journal of biological chemistry. 2000 275:12346-52. (Human) [PubMed:10766876]
2
Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity. Appierto V, Tiberio P, Cavadini E, Casalini P, Cappelletti G, Formelli F. Molecular cancer therapeutics. 2009 8:3360-8. [PubMed:19996280]
3
Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corra IR, Doxsey SJ, Brodsky FM. The Journal of cell biology. 2012 198:591-605. [PubMed:22891263] [PMC:PMC3514040]
4
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S. Oncogene. 2011 30:521-34. (WB) [Full Text Article] [PubMed:20838383]
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Viewing 1-13 of 13 items
CKAP5 / ch-TOG Antibody - Anti-CKAP5 / ch-TOG antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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Rabbit Polyclonal to Human CKAP5 / ch-TOG
Mouse, Rat, Mammal, Human
IHC, IHC-P
Unconjugated
100µl   $425.00
CKAP5 / ch-TOG Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human CKAP5 / ch-TOG
Frog, Chicken, Bovine, Mouse, Dog, Opossum, Rat, Chimpanzee, Human
IF, IHC-P, IP, WB
Unconjugated
50µl   $425.00
Select
Rabbit Polyclonal to Human CKAP5 / ch-TOG
Human
IF, IP, WB
Unconjugated
100µl   $560.00
CKAP5 / ch-TOG Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Rabbit Polyclonal (IgG) to Human CKAP5 / ch-TOG
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
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Rabbit Polyclonal (IgG) to Human CKAP5 / ch-TOG
Human
HRP Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human CKAP5 / ch-TOG
Human
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
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Rabbit Polyclonal (IgG) to Human CKAP5 / ch-TOG
Human
FITC Conjugated
50µg   $285.00; 100µg   $385.00
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Rabbit Polyclonal (IgG) to Human CKAP5 / ch-TOG
Mouse, Human
IP, WB
Unconjugated
100µl   0.2mg/ml   $405.00
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Rabbit Polyclonal (IgG) to Human CKAP5 / ch-TOG
Human
IP, WB
Unconjugated
100µl   0.2mg/ml   $405.00
Select
Rabbit Polyclonal (IgG) to Human CKAP5 / ch-TOG
Human
WB
Unconjugated
100µl   0.2mg/ml   $405.00
Select
Rabbit Polyclonal (IgG) to Human CKAP5 / ch-TOG
Mouse, Rat, Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
CKAP5 / ch-TOG Antibody
Select
Rabbit Polyclonal to Human CKAP5 / ch-TOG
Human
WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
CKAP5 / ch-TOG Antibody - Western blot analysis of extracts of various cells.
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Rabbit Polyclonal (IgG) to Human CKAP5 / ch-TOG
Mouse, Rat, Human
WB
AP Conjugated
20µl   $215.00; 50µl   $255.00; 100µl   $315.00; 200µl   $425.00

Viewing 1-13 of 13 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).