NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
|Gene Name:||carbonyl reductase 1|
|Synonyms:||CBR1, Carbonyl reductase 1, Carbonyl reductase (NADPH) 1, HCBR1, Prostaglandin 9-ketoreductase, SDR21C1, Carbonyl reductase [NADPH] 1, CBR, CRN, Prostaglandin-E(2) 9-reductase|
|Target Sequences:||NM_001757 NP_001748.1 P16152|
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