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CD44

CD44 molecule (Indian blood group)

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Gene Name: CD44 molecule (Indian blood group)
Synonyms: CD44, CDW44, CD44 antigen, Cell surface glycoprotein CD44, CSPG8, ECMR-III, Epican, HUTCH-I, LHR, MDU2, MC56, MIC4, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, PGP-I, Pgp1, Phagocytic glycoprotein I, MDU3, CD44R, HCELL, Heparan sulfate proteoglycan
Target Sequences: NM_000610 NP_000601.3 P16070

Publications (12)

1
Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Horwitz KB, Dye WW, Harrell JC, Kabos P, Sartorius CA. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:5774-9. (IHC) [PubMed:18391223] [PMC:PMC2311360]
2
Peritoneal tumor carcinomatosis: pharmacological targeting with hyaluronan-based bioconjugates overcomes therapeutic indications of current drugs. Montagner IM, Merlo A, Zuccolotto G, Renier D, Campisi M, Pasut G, Zanovello P, Rosato A. PloS one. 2014 9:e112240. (Flo; Human) [Full Text Article] [PubMed:25383653] [PMC:PMC4226476]
3
Drug conjugation to hyaluronan widens therapeutic indications for ovarian cancer. Montagner IM, Merlo A, Carpanese D, Zuccolotto G, Renier D, Campisi M, Pasut G, Zanovello P, Rosato A. Oncoscience. 2015 2:373-81. (Flo; Human) [PubMed:26097871] [PMC:PMC4468323]
4
Osteopontin inhibits HIF-2a mRNA expression in osteoarthritic chondrocytes. Cheng C, Zhang FJ, Tian J, Tu M, Xiong YL, Luo W, Li YS, Song BB, Gao SG, Lei GH. Experimental and therapeutic medicine. 2015 9:2415-2419. (Block; Human) [Full Text Article] [PubMed:26136997] [PMC:PMC4473661]
5
Auramine O, an incense smoke ingredient, promotes lung cancer malignancy. Tung JC, Huang WC, Yang JC, Chen GY, Fan CC, Chien YC, Lin PS, Candice Lung SC, Chang WC. Environmental toxicology. 2017 32:2379-2391. (IP; Human) [Full Text Article] [PubMed:28722353] [PMC:PMC5655719] Related Antibodies: LS-C44932.
6
Senescent Atrophic Epidermis Retains Lrig1+ Stem Cells and Loses Wnt Signaling, a Phenotype Shared with CD44KO Mice. Barnes L, Saurat JH, Kaya G. PloS one. 2017 January;12:e0169452. (Mouse) [Full Text Article] [PubMed:28099467] [PMC:PMC5242443] Related Antibodies: LS-C44149.
7
Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells. Scutera S, Salvi V, Lorenzi L, Piersigilli G, Lonardi S, Alotto D, Casarin S, Castagnoli C, Dander E, D'Amico G, Sozzani S, Musso T. Frontiers in immunology. 2018 June;9:1207. (Human) [Full Text Article] [PubMed:29910810] [PMC:PMC5992779]
8
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-?B signaling in resident macrophages. Hosoon Choi, Ryang Hwa Lee, Nikolay Bazhanov, Joo Youn Oh, Darwin J Prockop. Blood. 2011 July;118:330-8. [Full Text Article] [PubMed:21551236] [PMC:PMC3138686] Related Antibodies: LS-C34583.
9
Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article] [PubMed:29966501] [PMC:PMC6033701] Related Antibodies: LS-B5508.
10
A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo. Feng Liu, Hongyao Xu, He Huang. Stem cell research & therapy. 2019 July;10:201. [Full Text Article] [PubMed:31287023] [PMC:PMC6615105] Related Antibodies: LS-C13434.
11
CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma. Katrin Kleinmanns, Katharina Bischof, Shamundeeswari Anandan, Mihaela Popa, Lars A Akslen, Vibeke Fosse, Ida Tveit Karlsen, Bjørn T Gjertsen, Line Bjørge, Emmet McCormack. EBioMedicine. 2020 Jun;56:102782. [Full Text Article] [PubMed:32454401] [PMC:PMC7248428] Related Antibodies: LS-C46494.
12
Paclitaxel-hyaluronan hydrosoluble bioconjugate: mechanism of action in human bladder cancer cell lines. Montagner IM, Banzato A, Zuccolotto G, Renier D, Campisi M, Bassi P, Zanovello P, Rosato A. Urologic oncology. 2013 Oct;31:1261-9. [Full Text Article] [PubMed:22341413] Related Antibodies: LS-C87849.
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CD44 Antibody - Anti-CD44 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer Pathology
Cancer
CD44 Rat anti-Mouse Monoclonal (IM7) Antibody
Mouse, Canine, Feline, Equine, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
CD44 Antibody - Anti-CD44 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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CD44 Mouse anti-Human Monoclonal (8E2F3) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
CD44 Antibody - Anti-CD44 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Cancer Pathology
Cancer
CD44 Mouse anti-Human Monoclonal (MEM-85) Antibody
Human
ELISA, Flo, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$440
CD44 Antibody - Anti-CD44 antibody IHC of human uterus, smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer Pathology
Cancer
CD44 Mouse anti-Human Monoclonal (MEM-263) Antibody
Canine, Porcine, Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
CD44 Antibody - Flow cytometry analysis of human peripheral blood (lymphocyte gate) using anti-CD44 (MEM-263) PE conjugate.
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CD44 Mouse anti-Human Monoclonal (N-Terminus) (PE) (MEM-263) Antibody
Canine, Porcine, Human
Flo, IHC-P, IP, WB
PE Conjugated
100 Tests/$355
Select
CD44 Mouse anti-Human Monoclonal (Azide-free) (5F12) Antibody
Human
Block, Flo, IF
Unconjugated, Azide-free
0.1 ml/$532; 0.2 ml/$722
CD44 Antibody - Anti-CD44 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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CD44 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
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CD44 Rabbit anti-Human Polyclonal Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Human
ELISA, Flo, IF, IHC, IHC-P, IP, RIA, WB
Unconjugated
100 µg/$838
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CD44 Rabbit anti-Human Polyclonal Antibody
Rabbit, Mouse, Dog, Bovine, Pig, Human
ELISA, Flo, Func, IF, IP, RIA, WB
Unconjugated
100 µg/$818
CD44 Antibody - Formalin-fixed, paraffin-embedded human esophageal carcinoma stained with peroxidase-conjugate and AEC chromogen. Note cell membrane staining of tumor cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD44 Mouse anti-Human Monoclonal (Biotin) (156-3C11) Antibody
Human, Monkey, Baboon
Flo, IHC, IHC-P, IP, WB
Biotin Conjugated
500 µl/$724; 1 ml/$892
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CD44 Mouse anti-Mouse Monoclonal (5035-41.1D) Antibody
Mouse
Flo, IP
Unconjugated
0.25 mg/$444
Select
CD44 Mouse anti-Sheep Monoclonal (FITC) (25.32) Antibody
Sheep
Flo
FITC Conjugated
0.1 mg/$499
Select
CD44 Mouse anti-Rat Monoclonal (Biotin) (MRC OX-49) Antibody
Rat
Flo
Biotin Conjugated
100 µg/$326; 500 µg/$502
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CD44 Rat anti-Human Monoclonal Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$791
CD44 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
CD44 Mouse anti-Human Monoclonal (8E2F3) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC-P, WB
Unconjugated
0.1 ml/$460
Select
CD44 Rat anti-Mouse Monoclonal (9A4) Antibody
Mouse
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$363
CD44 Antibody - Surface staining of human peripheral blood using anti-CD44 (MEM-263) FITC conjugate.
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CD44 Mouse anti-Human Monoclonal (FITC) (MEM-263) Antibody
Canine, Porcine, Human
Flo, IHC-P, IP, WB
FITC Conjugated
100 Tests/$327
CD44 Antibody - Flow cytometry of CD44 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CD44 Mouse anti-Human Monoclonal (FITC) (BU52) Antibody
Human
Flo, IHC
FITC Conjugated
120 Tests/$411
CD44 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$653
CD44 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$772
CD44 Protein
Select
E. coli
6His-SUMO, N-terminus
80.1 kD
1 mg/$1,207; 100 µg/$408; 20 µg/$311
Select
CD44 Rat anti-Mouse Monoclonal (KM81) Antibody
Mouse
Flo
Unconjugated
250 µg/$349
Select
CD44 Mouse anti-Rat Monoclonal (MRC OX-49) Antibody
Rat
Flo
Unconjugated
250 µg/$330
CD44 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$809
CD44 Antibody - CD44 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human esophagus carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
CD44 Mouse anti-Human Monoclonal (Hermes-3) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$386
Viewing 1-25 of 501 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).