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Leptin

Leptin is a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Gene Name: Leptin
Synonyms: LEP, Leptin, LEPD, Obese protein, Obese, mouse, homolog of, Obesity factor, OBS, OB
Target Sequences: NM_000230 NP_000221.1 P41159

Publications (5)

1
Leptin as a potential target for estrogen receptor-positive breast cancer. Yom CK, Lee KM, Han W, Kim SW, Kim HS, Moon BI, Jeong KY, Im SA, Noh DY. Journal of breast cancer. 2013 16:138-45. (WB; Human) [Full Text Article] [PubMed:23843844] [PMC:PMC3706857] Related Antibodies: LS-C25172.
2
Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Jones HN, Olbrych SK, Smith KL, Cnota JF, Habli M, Ramos-Gonzales O, Owens KJ, Hinton AC, Polzin WJ, Muglia LJ, Hinton RB. Placenta. 2015 36:1078-86. (WB; Mouse) [Full Text Article] [PubMed:26278057] Related Antibodies: LS-B1459.
3
Delta-like protein 1 in the pituitary-adipose axis in the adult male mouse. Bello AR, Puertas-Avendaño RA, González-Gómez MJ, González-Gómez M, Laborda J, Damas C, Ruiz-Hidalgo M, Diaz C. Journal of neuroendocrinology. 2017 August;29: [Full Text Article] [PubMed:28718206] [PMC:PMC6084355]
4
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Kirthana Ganeshan, Joni Nikkanen, Kevin Man, Yew Ann Leong, Yoshitaka Sogawa, J Alan Maschek, Tyler Van Ry, D Nyasha Chagwedera, James E Cox, Ajay Chawla. Cell. 2019 April;177:399-413.e12. [Full Text Article] [PubMed:30853215] [PMC:PMC6456449]
5
Effects of 3-nitrooxypropanol on rumen fermentation, lactational performance, and resumption of ovarian cyclicity in dairy cows. A Melgar, M T Harper, J Oh, F Giallongo, M E Young, T L Ott, S Duval, A N Hristov. Journal of dairy science. 2020 Jan;103:410-432. [Full Text Article] [PubMed:31733848]
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).